| Literature DB >> 30367054 |
Takuya Osakada1,2, Kentaro K Ishii1,2, Hiromi Mori1,2, Ryo Eguchi1,2, David M Ferrero3, Yoshihiro Yoshihara2,4, Stephen D Liberles3, Kazunari Miyamichi5,6,7, Kazushige Touhara8,9,10.
Abstract
Mating drive is balanced by a need to safeguard resources for offspring, yet the neural basis for negative regulation of mating remains poorly understood. In rodents, pheromones critically regulate sexual behavior. Here, we observe suppression of adult female sexual behavior in mice by exocrine gland-secreting peptide 22 (ESP22), a lacrimal protein from juvenile mice. ESP22 activates a dedicated vomeronasal receptor, V2Rp4, and V2Rp4 knockout eliminates ESP22 effects on sexual behavior. Genetic tracing of ESP22-responsive neural circuits reveals a critical limbic system connection that inhibits reproductive behavior. Furthermore, V2Rp4 counteracts a highly related vomeronasal receptor, V2Rp5, that detects the male sex pheromone ESP1. Interestingly, V2Rp4 and V2Rp5 are encoded by adjacent genes, yet couple to distinct circuits and mediate opposing effects on female sexual behavior. Collectively, our study reveals molecular and neural mechanisms underlying pheromone-mediated sexual rejection, and more generally, how inputs are routed through olfactory circuits to evoke specific behaviors.Entities:
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Year: 2018 PMID： 30367054 PMCID： PMC6203846 DOI： 10.1038/s41467-018-07003-5
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 14.919