Literature DB >> 23314914

An unsaturated aliphatic alcohol as a natural ligand for a mouse odorant receptor.

Keiichi Yoshikawa1, Hiroaki Nakagawa, Naoki Mori, Hidenori Watanabe, Kazushige Touhara.   

Abstract

We report the identification of a physiological receptor-volatile pair in the mouse olfactory system. By activity-guided fractionation of exocrine gland extracts and subsequent chemical analysis, (Z)-5-tetradecen-1-ol was identified as a natural ligand for a mouse odorant receptor. (Z)-5-tetradecen-1-ol is excreted into male mouse urine under androgen control and enhances urine attractiveness to female mice. This report is to our knowledge the first to describe natural product-based deorphanization of an odorant receptor.

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Year:  2013        PMID： 23314914     DOI： 10.1038/nchembio.1164

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


  24 in total

1.  Functional identification and reconstitution of an odorant receptor in single olfactory neurons.

Authors:  K Touhara; S Sengoku; K Inaki; A Tsuboi; J Hirono; T Sato; H Sakano; T Haga
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-30       Impact factor: 11.205

Review 2.  Deorphanizing vertebrate olfactory receptors: recent advances in odorant-response assays.

Authors:  Kazushige Touhara
Journal:  Neurochem Int       Date:  2007-06-13       Impact factor: 3.921

3.  Structural basis for a broad but selective ligand spectrum of a mouse olfactory receptor: mapping the odorant-binding site.

Authors:  Sayako Katada; Takatsugu Hirokawa; Yuki Oka; Makiko Suwa; Kazushige Touhara
Journal:  J Neurosci       Date:  2005-02-16       Impact factor: 6.167

4.  (Z)-5-tetradecen-1-ol: A secondary pheromone of the yellowheaded spruce sawfly, and its relationship to (Z)-10-nonadecenal.

Authors:  R J Bartelt; R L Jones; T P Krick
Journal:  J Chem Ecol       Date:  1983-09       Impact factor: 2.626

5.  Encoding social signals in the mouse main olfactory bulb.

Authors:  Da Yu Lin; Shao-Zhong Zhang; Eric Block; Lawrence C Katz
Journal:  Nature       Date:  2005-02-20       Impact factor: 49.962

6.  The dose-response to testosterone propionate of preputial glands, pheromones and aggression in mice.

Authors:  R A Mugford; N W Nowell
Journal:  Horm Behav       Date:  1972-03       Impact factor: 3.587

7.  Effects of age at castration on testosterone induced aggression-promoting cues in groups of male mice.

Authors:  C M Evans; P F Brain
Journal:  Physiol Behav       Date:  1978-07

8.  Myr-Ric-8A enhances G(alpha15)-mediated Ca2+ response of vertebrate olfactory receptors.

Authors:  Keiichi Yoshikawa; Kazushige Touhara
Journal:  Chem Senses       Date:  2008-08-05       Impact factor: 3.160

9.  Identification and field testing of additional components of female sex pheromone of African armyworm,Spodoptera exempta (Lepidoptera: Noctuidae).

Authors:  A Cork; J Murlis; T Megenasa
Journal:  J Chem Ecol       Date:  1989-04       Impact factor: 2.626

10.  Receptors that couple to 2 classes of G proteins increase cAMP and activate CFTR expressed in Xenopus oocytes.

Authors:  Y Uezono; J Bradley; C Min; N A McCarty; M Quick; J R Riordan; C Chavkin; K Zinn; H A Lester; N Davidson
Journal:  Receptors Channels       Date:  1993
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  21 in total

Review 1.  The joy of sex pheromones.

Authors:  Carolina Gomez-Diaz; Richard Benton
Journal:  EMBO Rep       Date:  2013-09-13       Impact factor: 8.807

Review 2.  Aversion and attraction through olfaction.

Authors:  Qian Li; Stephen D Liberles
Journal:  Curr Biol       Date:  2015-02-02       Impact factor: 10.834

3.  Genetic dissection of pheromone processing reveals main olfactory system-mediated social behaviors in mice.

Authors:  Tomohiko Matsuo; Tatsuya Hattori; Akari Asaba; Naokazu Inoue; Nobuhiro Kanomata; Takefumi Kikusui; Reiko Kobayakawa; Ko Kobayakawa
Journal:  Proc Natl Acad Sci U S A       Date:  2015-01-06       Impact factor: 11.205

4.  Receptors: Chemical courtship in mice.

Authors:  Charles W Luetje
Journal:  Nat Chem Biol       Date:  2013-03       Impact factor: 15.040

Review 5.  Mammalian pheromones.

Authors:  Stephen D Liberles
Journal:  Annu Rev Physiol       Date:  2013-08-26       Impact factor: 19.318

6.  A 3D transcriptomics atlas of the mouse nose sheds light on the anatomical logic of smell.

Authors:  Mayra L Ruiz Tejada Segura; Eman Abou Moussa; Elisa Garabello; Thiago S Nakahara; Melanie Makhlouf; Lisa S Mathew; Li Wang; Filippo Valle; Susie S Y Huang; Joel D Mainland; Michele Caselle; Matteo Osella; Stephan Lorenz; Johannes Reisert; Darren W Logan; Bettina Malnic; Antonio Scialdone; Luis R Saraiva
Journal:  Cell Rep       Date:  2022-03-22       Impact factor: 9.423

Review 7.  Sexual attractiveness of male chemicals and vocalizations in mice.

Authors:  Akari Asaba; Tatsuya Hattori; Kazutaka Mogi; Takefumi Kikusui
Journal:  Front Neurosci       Date:  2014-08-05       Impact factor: 4.677

8.  Cross-Fostering of Male Mice Subtly Affects Female Olfactory Preferences.

Authors:  Ying-Juan Liu; Yao-Hua Zhang; Lai-Fu Li; Rui-Qing Du; Jin-Hua Zhang; Jian-Xu Zhang
Journal:  PLoS One       Date:  2016-01-12       Impact factor: 3.240

9.  Extreme expansion of the olfactory receptor gene repertoire in African elephants and evolutionary dynamics of orthologous gene groups in 13 placental mammals.

Authors:  Yoshihito Niimura; Atsushi Matsui; Kazushige Touhara
Journal:  Genome Res       Date:  2014-07-22       Impact factor: 9.043

10.  CD36 is expressed in a defined subpopulation of neurons in the olfactory epithelium.

Authors:  André Machado Xavier; Raissa Guimarães Ludwig; Maíra Harume Nagai; Tiago Jonas de Almeida; Hebe Mizuno Watanabe; Marcio Yukio Hirata; Tatiana Rosado Rosenstock; Fabio Papes; Bettina Malnic; Isaias Glezer
Journal:  Sci Rep       Date:  2016-05-05       Impact factor: 4.379
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