Literature DB >> 3036556

Phospholipase C activation via a GTP-binding protein in tumoral islet cells stimulated by carbamylcholine.

F Blachier, W J Malaisse.   

Abstract

Carbamylcholine and GTP act synergistically in stimulating the production of [3H]inositol-1-phosphate by digitonized tumoral islet cells (RINm5F line) prelabeled with myo-[2-3H(N)]inositol. The response to these two agents is similar to that evoked by GTP gamma S. These findings suggest that a GTP-binding regulatory protein couples the occupancy of muscarinic receptors to activation of phospholipase C in pancreatic islet cells.

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Year:  1987        PMID： 3036556     DOI： 10.1007/BF02126344

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  9 in total

1.  Stimulation by cholera toxin of ADP-ribosylation of membrane proteins, adenylate cyclase and insulin release in pancreatic islets.

Authors:  M Svoboda; P Garcia-Morales; S P Dufrane; A Sener; I Valverde; J Christophe; W J Malaisse
Journal:  Cell Biochem Funct       Date:  1985-01       Impact factor: 3.685

Review 2.  Stimulus-secretion coupling in the pancreatic B-cell: the cholinergic pathway for insulin release.

Authors:  W J Malaisse
Journal:  Diabetes Metab Rev       Date:  1986

3.  Normal p21N-ras couples bombesin and other growth factor receptors to inositol phosphate production.

Authors:  M J Wakelam; S A Davies; M D Houslay; I McKay; C J Marshall; A Hall
Journal:  Nature       Date:  1986 Sep 11-17       Impact factor: 49.962

4.  The stimulus-secretion coupling of glucose-induced insulin release. I. Interaction of epinephrine and alkaline earth cations.

Authors:  W J Malaisse; G Brisson; F Malaisse-Lagae
Journal:  J Lab Clin Med       Date:  1970-12

5.  Potential role for a guanine nucleotide regulatory protein in chemoattractant receptor mediated polyphosphoinositide metabolism, Ca++ mobilization and cellular responses by leukocytes.

Authors:  M W Verghese; C D Smith; R Snyderman
Journal:  Biochem Biophys Res Commun       Date:  1985-03-15       Impact factor: 3.575

6.  Coupling of the thyrotropin-releasing hormone receptor to phospholipase C by a GTP-binding protein distinct from the inhibitory or stimulatory GTP-binding protein.

Authors:  D L Aub; E A Frey; R D Sekura; T E Cote
Journal:  J Biol Chem       Date:  1986-07-15       Impact factor: 5.157

7.  Effect of Bordetella pertussis toxin on ADP-ribosylation of membrane proteins, adenylate cyclase activity and insulin release in rat pancreatic islets.

Authors:  W J Malaisse; M Svoboda; S P Dufrane; F Malaisse-Lagae; J Christophe
Journal:  Biochem Biophys Res Commun       Date:  1984-10-15       Impact factor: 3.575

8.  Hexose metabolism in pancreatic islets. Galactose transport, phosphorylation and oxidation.

Authors:  M H Giroix; F Malaisse-Lagae; A Sener; W J Malaisse
Journal:  Mol Cell Biochem       Date:  1985-02       Impact factor: 3.396

9.  Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides.

Authors:  M J Berridge; R M Dawson; C P Downes; J P Heslop; R F Irvine
Journal:  Biochem J       Date:  1983-05-15       Impact factor: 3.857
  9 in total
  1 in total

1.  Prostaglandin E2 inhibits phosphoinositide metabolism in isolated pancreatic islets.

Authors:  S G Laychock
Journal:  Biochem J       Date:  1989-05-15       Impact factor: 3.857
  1 in total

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