Literature DB >> 6388572

Effect of Bordetella pertussis toxin on ADP-ribosylation of membrane proteins, adenylate cyclase activity and insulin release in rat pancreatic islets.

W J Malaisse, M Svoboda, S P Dufrane, F Malaisse-Lagae, J Christophe.   

Abstract

Exposure of rat pancreatic islet membranes to [alpha-32P]-NAD+ in the presence of Bordetella Pertussis toxin (islet-activating protein) reveals the ADP-ribosylation of a peptide with a Mr close to 41 kDa, which corresponds to the alpha-subunit of the guanine nucleotide regulatory protein Ni. Islets removed from rats pretreated with the Bordetella Pertussis toxin display a specific increase in adenylate cyclase responsiveness to GTP and are characterized by a resistance to the inhibitory action of alpha2-adrenergic agonists upon either adenylate cyclase activity or glucose-induced insulin release.

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Year:  1984        PMID： 6388572     DOI： 10.1016/0006-291x(84)90935-5

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  9 in total

Review 1.  Type V protein secretion pathway: the autotransporter story.

Authors:  Ian R Henderson; Fernando Navarro-Garcia; Mickaël Desvaux; Rachel C Fernandez; Dlawer Ala'Aldeen
Journal:  Microbiol Mol Biol Rev       Date:  2004-12       Impact factor: 11.056

2.  Effects of Bordetella pertussis toxin on catecholamine inhibition of insulin release from intact and electrically permeabilized rat islets.

Authors:  S J Persaud; P M Jones; S L Howell
Journal:  Biochem J       Date:  1989-03-15       Impact factor: 3.857

3.  Activation of alpha-2-adrenoceptors results in an increase in F-actin formation in HIT-T15 pancreatic B-cells.

Authors:  H C Cable; A el-Mansoury; N G Morgan
Journal:  Biochem J       Date:  1995-04-01       Impact factor: 3.857

Review 4.  The role of cyclic AMP in insulin release.

Authors:  W J Malaisse; F Malaisse-Lagae
Journal:  Experientia       Date:  1984-10-15

5.  Phospholipase C activation via a GTP-binding protein in tumoral islet cells stimulated by carbamylcholine.

Authors:  F Blachier; W J Malaisse
Journal:  Experientia       Date:  1987-06-15

6.  Possible participation of an islet B-cell calcium-sensing receptor in insulin release.

Authors:  W J Malaisse; K Louchami; A Laghmich; L Ladrière; M Morales; M L Villanueva-Peñacarrillo; I Valverde; J Rasschaert
Journal:  Endocrine       Date:  1999-12       Impact factor: 3.633

7.  Effect of a phospho-oligosaccharidic putative insulin messenger on insulin release in rats.

Authors:  W J Malaisse; A Albor; F Blachier; I Valverde; A Sener; J M Mato
Journal:  Diabetologia       Date:  1989-05       Impact factor: 10.122

Review 8.  In Vivo Models and In Vitro Assays for the Assessment of Pertussis Toxin Activity.

Authors:  Marieke Esther Hoonakker
Journal:  Toxins (Basel)       Date:  2021-08-12       Impact factor: 4.546

9.  Gi proteins regulate adenylyl cyclase activity independent of receptor activation.

Authors:  Caroline Bull Melsom; Øivind Ørstavik; Jan-Bjørn Osnes; Tor Skomedal; Finn Olav Levy; Kurt Allen Krobert
Journal:  PLoS One       Date:  2014-09-09       Impact factor: 3.240
  9 in total

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