Literature DB >> 2549955

Prostaglandin E2 inhibits phosphoinositide metabolism in isolated pancreatic islets.

S G Laychock1.   

Abstract

Isolated islets of the rat labelled with myo-[3H]inositol showed decreased accumulation of total inositol phosphates (InsPs) and [3H]polyphosphoinositide hydrolysis in response to glucose after preincubation with prostaglandin E2 (PGE2). The response was concentration-dependent and specific for PGE2. PGE2 did not affect basal [3H]phosphoinositide hydrolysis or InsPs accumulation. Pertussis-toxin pretreatment antagonized the response to PGE2, whereas 8-bromo cyclic AMP was without effect. The PGE2-induced decrease in InsPs may contribute to the suppression of insulin secretion.

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Year:  1989        PMID： 2549955      PMCID： PMC1138660          DOI： 10.1042/bj2600291

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  22 in total

1.  Cyclic AMP-antagonist, a second messenger for insulin action, inhibits glucose-stimulated insulin secretion in isolated islets of Chinese hamsters.

Authors:  H J Partke; H K Wasner
Journal:  Adv Exp Med Biol       Date:  1986       Impact factor: 2.622

2.  Phospholipase C activation via a GTP-binding protein in tumoral islet cells stimulated by carbamylcholine.

Authors:  F Blachier; W J Malaisse
Journal:  Experientia       Date:  1987-06-15

3.  Prostaglandin E2 and alpha 2 adrenoceptor agonists inhibit the pentose phosphate shunt in pancreatic islets.

Authors:  S G Laychock
Journal:  Arch Biochem Biophys       Date:  1989-02-15       Impact factor: 4.013

4.  The digitonin-permeabilized pancreatic islet model. Effect of myo-inositol 1,4,5-trisphosphate on Ca2+ mobilization.

Authors:  B A Wolf; P G Comens; K E Ackermann; W R Sherman; M L McDaniel
Journal:  Biochem J       Date:  1985-05-01       Impact factor: 3.857

5.  Glucose-induced accumulation of inositol trisphosphates in isolated pancreatic islets. Predominance of the 1,3,4-isomer.

Authors:  J Turk; B A Wolf; M L McDaniel
Journal:  Biochem J       Date:  1986-07-01       Impact factor: 3.857

6.  Arachidonic acid metabolism and insulin secretion by isolated human pancreatic islets.

Authors:  J Turk; J H Hughes; R A Easom; B A Wolf; D W Scharp; P E Lacy; M L McDaniel
Journal:  Diabetes       Date:  1988-07       Impact factor: 9.461

7.  Muscarinic-agonist and guanine nucleotide activation of polyphosphoinositide phosphodiesterase in isolated islet-cell membranes.

Authors:  M E Dunlop; R G Larkins
Journal:  Biochem J       Date:  1986-12-15       Impact factor: 3.857

8.  Receptor-mediated adenylate cyclase-coupled mechanism for PGE2 inhibition of insulin secretion in HIT cells.

Authors:  R P Robertson; P Tsai; S A Little; H J Zhang; T F Walseth
Journal:  Diabetes       Date:  1987-09       Impact factor: 9.461

9.  Identification and metabolism of polyphosphoinositides in isolated islets of Langerhans.

Authors:  S G Laychock
Journal:  Biochem J       Date:  1983-10-15       Impact factor: 3.857

10.  Effects of guanosine 3',5'-monophosphate on glucose utilization in isolated islets of Langerhans.

Authors:  S G Laychock
Journal:  Endocrinology       Date:  1987-02       Impact factor: 4.736
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  1 in total

1.  A farnesylated G-protein suppresses Akt phosphorylation in INS 832/13 cells and normal rat islets: regulation by pertussis toxin and PGE₂.

Authors:  Chandrashekara N Kyathanahalli; Anjaneyulu Kowluru
Journal:  Biochem Pharmacol       Date:  2011-03-23       Impact factor: 5.858
  1 in total

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