Literature DB >> 30354177

Current preoperative antisepsis in neurosurgery: an example of the challenges in implementing evidence-based medicine to surgical practice.

Sachdev Bobby1, Jenkinson Michael D2,3, Patel Hiren4, Davies Benjamin5.   

Abstract

INTRODUCTION: Surgical site infection is associated with significant morbidity and mortality. Effective preoperative skin decolonisation is an important preventative strategy. The National Institute for Health and Care Excellence clinical guidelines recommend decolonisation using chlorhexidine gluconate (CHG) or povidone iodine (PVI). Current evidence indicates that CHG is more effective, while the combination of CHG and PVI is greater still. This study describes current practice among neurosurgeons in the UK, including differences between trainees and consultants, to review compliance with the latest evidence.
MATERIALS AND METHODS: A Society of British Neurosurgical Surgeons approved national, multicentre questionnaire was circulated online. A total of 74 complete responses were obtained from 27 trainees and 47 consultants, representing 28 of 37 neurosurgical centres.
RESULTS: Of the total responding centres, 36 (49%) used a single agent and 38 (51%) used a dual-agent preparation. One respondent used Tisept®. Seventy (95%) used alcohol in some form and none used aqueous CHG. Trainees were more likely to use a dual-agent preparation (P = 0.025). Forty-seven (63%) prepared the skin three or more times, with trainees preparing the skin more times than consultants (P = 0.002).
CONCLUSION: Neurosurgical practice adheres to national clinical guidelines but not the latest evidence from the literature. Given the weighting placed on randomised controlled trials, such a trial may be required to standardise practice that is likely to reduce surgical site infection.

Entities:  

Keywords:  Chlorhexidine gluconate; Neurosurgery; Povidone iodine; Preoperative decolonisation; Surgical site infection

Mesh:

Substances:

Year:  2018        PMID: 30354177      PMCID: PMC6432964          DOI: 10.1308/rcsann.2018.0174

Source DB:  PubMed          Journal:  Ann R Coll Surg Engl        ISSN: 0035-8843            Impact factor:   1.891


  23 in total

1.  The impact of surgical-site infections in the 1990s: attributable mortality, excess length of hospitalization, and extra costs.

Authors:  K B Kirkland; J P Briggs; S L Trivette; W E Wilkinson; D J Sexton
Journal:  Infect Control Hosp Epidemiol       Date:  1999-11       Impact factor: 3.254

2.  Guideline for prevention of surgical site infection, 1999. Hospital Infection Control Practices Advisory Committee.

Authors:  A J Mangram; T C Horan; M L Pearson; L C Silver; W R Jarvis
Journal:  Infect Control Hosp Epidemiol       Date:  1999-04       Impact factor: 3.254

Review 3.  Systematic review and cost analysis comparing use of chlorhexidine with use of iodine for preoperative skin antisepsis to prevent surgical site infection.

Authors:  Ingi Lee; Rajender K Agarwal; Bruce Y Lee; Neil O Fishman; Craig A Umscheid
Journal:  Infect Control Hosp Epidemiol       Date:  2010-10-22       Impact factor: 3.254

4.  Efficacy of concurrent application of chlorhexidine gluconate and povidone iodine against six nosocomial pathogens.

Authors:  Michele J Anderson; Mary E Horn; Ying-Chi Lin; Patrick J Parks; Marnie L Peterson
Journal:  Am J Infect Control       Date:  2010-10-30       Impact factor: 2.918

5.  Patients' experiences of acquiring a deep surgical site infection: an interview study.

Authors:  Annette Erichsen Andersson; Ingrid Bergh; Jon Karlsson; Kerstin Nilsson
Journal:  Am J Infect Control       Date:  2010-11       Impact factor: 2.918

Review 6.  Systematic review and meta-analysis of preoperative antisepsis with chlorhexidine versus povidone-iodine in clean-contaminated surgery.

Authors:  A Noorani; N Rabey; S R Walsh; R J Davies
Journal:  Br J Surg       Date:  2010-11       Impact factor: 6.939

7.  De Testimonio: on the evidence for decisions about the use of therapeutic interventions.

Authors:  Michael Rawlins
Journal:  Clin Med (Lond)       Date:  2008-12       Impact factor: 2.659

8.  Chlorhexidine-Alcohol versus Povidone-Iodine for Surgical-Site Antisepsis.

Authors:  Rabih O Darouiche; Matthew J Wall; Kamal M F Itani; Mary F Otterson; Alexandra L Webb; Matthew M Carrick; Harold J Miller; Samir S Awad; Cynthia T Crosby; Michael C Mosier; Atef Alsharif; David H Berger
Journal:  N Engl J Med       Date:  2010-01-07       Impact factor: 91.245

9.  Evaluation of the skin flora after chlorhexidine and povidone-iodine preparation in neurosurgical practice.

Authors:  Aslan Guzel; Tuncer Ozekinci; Umit Ozkan; Yusuf Celik; Adnan Ceviz; Deniz Belen
Journal:  Surg Neurol       Date:  2008-03-04

10.  Effects of preoperative skin preparation on postoperative wound infection rates: a prospective study of 3 skin preparation protocols.

Authors:  Brian R Swenson; Traci L Hedrick; Rosemarie Metzger; Hugo Bonatti; Timothy L Pruett; Robert G Sawyer
Journal:  Infect Control Hosp Epidemiol       Date:  2009-10       Impact factor: 3.254

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  1 in total

Review 1.  Enhanced recovery after surgery protocols for outpatient operations in otolaryngology: Review of literature.

Authors:  Kevin Chorath; Sara Hobday; Neeraj V Suresh; Beatrice Go; Alvaro Moreira; Karthik Rajasekaran
Journal:  World J Otorhinolaryngol Head Neck Surg       Date:  2022-04-18
  1 in total

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