Magnetic solid-phase extraction of fluoroquinolones from water samples using titanium-based metal-organic framework functionalized magnetic microspheres.

In this study, a unique core-shell titanium-based metal-organic framework (MOF) functionalized magnetic microsphere was constructed and utilized as magnetic adsorbent for enrichment of five fluoroquinolones from water samples. The received magnetic MOF nanocomposite, denoted as Fe3O4@Cys@MIL125-NH2, showed strong magnetic responsiveness, and good hydrophilicity, as well as excellent affinity to the target analytes. Under optimal conditions, the developed magnetic solid-phase extraction (MSPE) method, combined with ultra-high performance liquid chromatography (UPLC), showed good linearity within the studied concentration range, and low limits of detection (0.05-0.2 μg L-1). The accuracy of the developed method was evaluated by measuring the extraction recovery of the spiked tap water and river water samples. The satisfactory recoveries of five fluoroquinolones were in the range of 83.8-109.4% with the RSDs lower than 8.9%. These results indicated that the as-prepared Fe3O4-Cys@MIL125-NH2 is a promising magnetic adsorbent for efficient enrichment of fluoroquinolones from tap water and environmental water samples.