| Literature DB >> 30352077 |
Dohyun Kim1, Sungmin You2, Soonwon So2, Jongshill Lee2, Sunhyun Yook2, Dong Pyo Jang2, In Young Kim2, Eunkyoung Park3, Kyeongwon Cho3, Won Chul Cha4,5, Dong Wook Shin5,6, Baek Hwan Cho3,7, Hoon-Ki Park8.
Abstract
In a mass casualty incident, the factors that determine the survival rate of injured patients are diverse, but one of the key factors is the time for triage. Additionally, the main factor that determines the time of triage is the number of medical personnel. However, when relying on a small number of medical personnel, the ability to increase survivability is limited. Therefore, developing a classification model for survival prediction that can quickly and precisely triage via wearable devices without medical personnel is important. In this study, we designed a consciousness index to substitute the factor by manpower and improved the classification accuracy by applying a machine learning algorithm. First, logistic regression analysis using vital signs and a consciousness index capable of remote monitoring through wearable devices confirmed the high efficiency of the consciousness index. We then developed a classification model with high accuracy which corresponds to existing injury severity scoring systems through the machine learning algorithms. We extracted 460,865 cases which met our criteria for developing the survival prediction from the national sample project in the national trauma databank which contains 408,316 cases of blunt injury and 52,549 cases of penetrating injury. Among the dataset, 17,918 (3.9%) cases died while the other survived. The AUCs with 95% confidence intervals (CIs) for the different models with the proposed simplified consciousness score as follows: RTS (as baseline), 0.78 (95% CI = 0.775 to 0.785); logistic regression, 0.87 (95% CI = 0.862 to 0.870); random forest, 0.87 (95% CI = 0.862 to 0.872); deep neural network, 0.89 (95% CI = 0.882 to 0.890). As a result, we confirmed the possibility of remote triage using a wearable device. It is expected that the time required for triage can be effectively reduced by using the developed classification model of survival prediction.Entities:
Mesh:
Year: 2018 PMID: 30352077 PMCID: PMC6198975 DOI: 10.1371/journal.pone.0206006
Source DB: PubMed Journal: PLoS One ISSN: 1932-6203 Impact factor: 3.240
Score table of Glasgow coma scale (GCS) and simplified consciousness score (SCS).
| Criteria | GCS score | SCS score | |
|---|---|---|---|
| Spontaneous | 4 | - | |
| To speech | 3 | ||
| To pain | 2 | ||
| None | 1 | ||
| Oriented | 5 | 2 | |
| Confused conversation | 4 | ||
| Inappropriate word | 3 | ||
| Incomprehensible sounds | 2 | 1 | |
| None | 1 | ||
| Obeys commands | 6 | 2 | |
| Localizes pain | 5 | ||
| Normal flexion (withdrawal) | 4 | 1 | |
| Abnormal flexion (decorticate) | 3 | ||
| Extension (decerebrate) | 2 | ||
| None | 1 | ||
| 3–15 | 2–4 | ||
Fig 1The flowchart for patient data extraction procedure.
Characteristics of each input variable from the patient data in the NTDB.
| Input Variable | Units | Death | Survival | P-value |
|---|---|---|---|---|
| AGE | years (SD) | 58.4 (22.7) | 48.8 (21.1) | <0.001 |
| SBP | mm HG (SD) | 122.9 (53.1) | 134.9 (29.8) | <0.001 |
| HR | beat per minute (SD) | 86.6 (34.9) | 90.7 (20.9) | <0.001 |
| RR | breath per minute (SD) | 15.1 (9.8) | 18.4 (5.3) | <0.001 |
| SCS | score (SD) | 2.9 (1.0) | 3.8 (0.5) | <0.001 |
| GCS | score (SD) | 8.5 (5.3) | 14.0 (2.6) | <0.001 |
* The p-values were estimated using one-way analysis of variance
Performance of the machine learning algorithms for survivability predictions.
| Algorithms | Input Variables | Mean AUC | Standard Deviation | 95% Confidence Interval | |
|---|---|---|---|---|---|
| LCL | UCL | ||||
| RTS (Baseline) | SBP, RR, GCS | 0.78 | 0.007 | 0.775 | 0.785 |
| Logistic Regression | Age, SBP, RR, HR | 0.71 | 0.009 | 0.705 | 0.718 |
| Logistic Regression | Age, SBP, RR, HR, SCS | 0.87 | 0.005 | 0.862 | 0.870 |
| Logistic Regression | Age, SBP, RR, HR, GCS | 0.88 | 0.005 | 0.872 | 0.880 |
| Random Forest | Age, SBP, RR, HR, SCS | 0.87 | 0.007 | 0.862 | 0.872 |
| Neural Network | Age, SBP, RR, HR, GCS | 0.89 | 0.007 | 0.885 | 0.895 |
| TRISS | Age, SBP, RR, GCS, ISS | 0.90 | 0.005 | 0.901 | 0.909 |
* The standard errors were estimated by the jackknife procedure for 10-fold cross-validation results.
Comparison of false positive ratio (FPR) and true positive ratio (TPR) for machine learning algorithms for survivability predictions.
| Algorithms | Input Variables | FPR (%) | TPR (%) |
|---|---|---|---|
| RTS (Baseline) | GCS, SBP, RR | 33.9 | 85.8 |
| Logistic Regression | Age, SBP, RR, HR, SCS | 21.2 | 78.8 |
| Random Forest | Age, SBP, RR, HR, SCS | 20.8 | 77.5 |
| Neural Network | Age, SBP, RR, HR, GCS | 19.5 | 80.9 |
| TRISS | Age, SBP, RR, GCS, ISS | 18.5 | 84.0 |
Fig 2ROC curves with AUC values for the neural networks and RTS.
Comparison between the neural network with simplified consciousness score (SCS), the neural network with Glasgow coma scale (GCS) and existing triage model, RTS. Neural networks developed without the injury severity score (ISS) outperformed the revised trauma score (RTS).
Comparison of the predicted survival score for the total dataset and each injury mechanism with the neural network.
| Total Dataset | Blunt Dataset | Penetrating Dataset | |
|---|---|---|---|
| 0.9906 (± 0.00008) | 0.9910 (± 0.00008) | 0.9877 (± 0.0003) | |
| 0.8662 (± 0.0015) | 0.8673 (± 0.0004) | 0.8603 (± 0.0032) |
Feature ranking of the machine learning algorithms; a lower number indicates a greater importance.
| Ranking | Age | SBP | RR | HR | SCS |
|---|---|---|---|---|---|
| Logistic Regression | 5 | 2 | 3 | 4 | |
| Random Forest | 4 | 2 | 3 | 5 | |
| Neural Network | 5 | 3 | 2 | 4 | |
| Average Ranking | 4.6 | 2.3 | 2.6 | 4.3 |
Performance of the machine learning algorithms for survivability predictions.
The standard errors were estimated by the jack-knife procedure.
| Algorithms | Input Variables | AUC | Standard Error | 95% Confidence Interval | |
|---|---|---|---|---|---|
| LCL | UCL | ||||
| TRISS | Age, SBP, RR, GCS, ISS | 0.90 | 0.005 | 0.901 | 0.909 |
| Neural Network | Age, SBP, RR, HR, GCS, ISS | 0.93 | 0.005 | 0.922 | 0.930 |
Fig 3ROC curves with AUC values for the neural network and TRISS.
Comparison between the additionally developed neural network models with the injury severity score (ISS) and existing triage model, TRISS. In both model, with SCS and GCS, the neural network developed with the ISS also outperformed the trauma and injury severity score (TRISS).