Agata Mikolajczyk1, Veria Khosrawipour2, Justyna Schubert3, Michal Plociennik4, Kacper Nowak4, Christian Fahr5, Haris Chaudhry6, Tanja Khosrawipour7,8. 1. Department of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland. 2. Department of Orthopedic and Trauma Surgery, Ortho Clinic, Dortmund, Dortmund, Germany. 3. Department of Food Hygiene and Consumer Health Protection, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland. 4. School of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland. 5. Department of Urology, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany. 6. Division of Colorectal Surgery, Department of Surgery, University of California, Irvine, CA, U.S.A. 7. Division of Colorectal Surgery, Department of Surgery, University of California, Irvine, CA, U.S.A. tkhosrawipour@gmail.com. 8. Department of Surgery (A), University Hospital Duesseldorf, Duesseldorf, Germany.
Abstract
BACKGROUND: Pressurized aerosol chemotherapy (PAC) is a novel approach to the treatment of surface malignancies. This study aimed to investigate whether PAC is a feasible treatment of early-stage bladder cancer. MATERIALS AND METHODS: PAC via inserted microcatheter was performed on a fresh urinary bladder in a post-mortem swine model (n=3), creating a pressurized doxorubicin chemoaerosol. Drug penetration of aerosolized doxorubicin at different concentrations (3 mg/50 ml, 9 mg/50 ml and 15 mg/50 ml) and different locations on the mucosa was measured via fluorescence microscopy. RESULTS: Mean endoluminal penetration rates for the urothelium following PAC reached 149±61 μm (using 15 mg/50 ml). Doxorubicin penetration was significantly increased with higher drug concentration (15 vs. 3 mg/50 ml: p<0.01). This study demonstrated the feasibility of PAC for intravesical use. CONCLUSION: PAC is a feasible minimally-invasive approach to the treatment of early-stage bladder cancer. Copyright
BACKGROUND: Pressurized aerosol chemotherapy (PAC) is a novel approach to the treatment of surface malignancies. This study aimed to investigate whether PAC is a feasible treatment of early-stage bladder cancer. MATERIALS AND METHODS:PAC via inserted microcatheter was performed on a fresh urinary bladder in a post-mortem swine model (n=3), creating a pressurized doxorubicin chemoaerosol. Drug penetration of aerosolized doxorubicin at different concentrations (3 mg/50 ml, 9 mg/50 ml and 15 mg/50 ml) and different locations on the mucosa was measured via fluorescence microscopy. RESULTS: Mean endoluminal penetration rates for the urothelium following PAC reached 149±61 μm (using 15 mg/50 ml). Doxorubicin penetration was significantly increased with higher drug concentration (15 vs. 3 mg/50 ml: p<0.01). This study demonstrated the feasibility of PAC for intravesical use. CONCLUSION:PAC is a feasible minimally-invasive approach to the treatment of early-stage bladder cancer. Copyright
Authors: Veria Khosrawipour; Tanja Khosrawipour; Thomas Albert Falkenstein; David Diaz-Carballo; Eckart Förster; Aras Osma; Irenäus Anton Adamietz; Jürgen Zieren; Khashayar Fakhrian Journal: Anticancer Res Date: 2016-09 Impact factor: 2.480
Authors: Juan Palou-Redorta; Morgan Rouprêt; Jack R Gallagher; Kylee Heap; Catherine Corbell; Brent Schwartz Journal: World J Urol Date: 2013-08-02 Impact factor: 4.226
Authors: Wiebke Solass; Reinhold Kerb; Thomas Mürdter; Urs Giger-Pabst; Dirk Strumberg; Clemens Tempfer; Jürgen Zieren; Matthias Schwab; Marc André Reymond Journal: Ann Surg Oncol Date: 2013-09-05 Impact factor: 5.344