Literature DB >> 30344913

Famotidine, an Antiulcer Agent, Strongly Inhibits Helicobacter pylori and Human Carbonic Anhydrases.

Andrea Angeli1, Marta Ferraroni2, Claudiu T Supuran1.   

Abstract

Famotidine, an antiulcer drug incorporating a sulfamide motif, was investigated as carbonic anhydrase inhibitor (CAI). It acts as a nanomolar inhibitor of several human (hCA II, VI, VII and XII) and Helicobacter pylori CAs. The high resolution X-ray structures of famotidine bound to hCA I and II revealed interesting aspects related to its CA inhibition mechanism, offering the possibility to develop antibacterials with a novel mechanism of action.

Entities:  

Year:  2018        PMID： 30344913      PMCID： PMC6187404          DOI： 10.1021/acsmedchemlett.8b00334

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


  20 in total

Review 1.  Carbonic anhydrases: novel therapeutic applications for inhibitors and activators.

Authors:  Claudiu T Supuran
Journal:  Nat Rev Drug Discov       Date:  2008-02       Impact factor: 84.694

Review 2.  Structure and function of carbonic anhydrases.

Authors:  Claudiu T Supuran
Journal:  Biochem J       Date:  2016-07-15       Impact factor: 3.857

3.  Structure-Activity Relationship for Sulfonamide Inhibition of Helicobacter pylori α-Carbonic Anhydrase.

Authors:  Joyanta K Modak; Yu C Liu; Claudiu T Supuran; Anna Roujeinikova
Journal:  J Med Chem       Date:  2016-12-08       Impact factor: 7.446

Review 4.  The history and rationale of using carbonic anhydrase inhibitors in the treatment of peptic ulcers. In memoriam Ioan Puşcaş (1932-2015).

Authors:  György M Buzás; Claudiu T Supuran
Journal:  J Enzyme Inhib Med Chem       Date:  2015-06-25       Impact factor: 5.051

5.  The carbon dioxide hydration activity of carbonic anhydrase. I. Stop-flow kinetic studies on the native human isoenzymes B and C.

Authors:  R G Khalifah
Journal:  J Biol Chem       Date:  1971-04-25       Impact factor: 5.157

6.  The isoenzymes of carbonic anhydrase: tissue, subcellular distribution and functional significance, with particular reference to the intestinal tract.

Authors:  M J Carter; D S Parsons
Journal:  J Physiol       Date:  1971-05       Impact factor: 5.182

7.  The periplasmic alpha-carbonic anhydrase activity of Helicobacter pylori is essential for acid acclimation.

Authors:  Elizabeth A Marcus; Amiel P Moshfegh; George Sachs; David R Scott
Journal:  J Bacteriol       Date:  2005-01       Impact factor: 3.490

8.  Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs.

Authors:  Isao Nishimori; Tomoko Minakuchi; Kaori Morimoto; Shuichi Sano; Saburo Onishi; Hiroaki Takeuchi; Daniela Vullo; Andrea Scozzafava; Claudiu T Supuran
Journal:  J Med Chem       Date:  2006-03-23       Impact factor: 7.446

9.  Carbonic anhydrase inhibitors: the beta-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors.

Authors:  Isao Nishimori; Tomoko Minakuchi; Takuhiro Kohsaki; Saburo Onishi; Hiroaki Takeuchi; Daniela Vullo; Andrea Scozzafava; Claudiu T Supuran
Journal:  Bioorg Med Chem Lett       Date:  2007-04-25       Impact factor: 2.823

10.  Amount and distribution of carbonic anhydrases CA I and CA II in the gastrointestinal tract.

Authors:  G Lönnerholm; O Selking; P J Wistrand
Journal:  Gastroenterology       Date:  1985-05       Impact factor: 22.682
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  12 in total

1.  Chemical Probes for Histamine Receptor Subtypes.

Authors:  Markus Falkenstein; Milica Elek; Holger Stark
Journal:  Curr Top Behav Neurosci       Date:  2022

2.  Inhibition of α-, β-, γ-, δ-, ζ- and η-class carbonic anhydrases from bacteria, fungi, algae, diatoms and protozoans with famotidine.

Authors:  Andrea Angeli; Mariana Pinteala; Stelian S Maier; Sonia Del Prete; Clemente Capasso; Bogdan C Simionescu; Claudiu T Supuran
Journal:  J Enzyme Inhib Med Chem       Date:  2019-12       Impact factor: 5.051

3.  Benzylaminoethyureido-Tailed Benzenesulfonamides: Design, Synthesis, Kinetic and X-ray Investigations on Human Carbonic Anhydrases.

Authors:  Majid Ali; Murat Bozdag; Umar Farooq; Andrea Angeli; Fabrizio Carta; Paola Berto; Giuseppe Zanotti; Claudiu T Supuran
Journal:  Int J Mol Sci       Date:  2020-04-07       Impact factor: 5.923

Review 4.  Carbonic Anhydrases: New Perspectives on Protein Functional Role and Inhibition in Helicobacter pylori.

Authors:  Cristina Campestre; Viviana De Luca; Simone Carradori; Rossella Grande; Vincenzo Carginale; Andrea Scaloni; Claudiu T Supuran; Clemente Capasso
Journal:  Front Microbiol       Date:  2021-03-19       Impact factor: 5.640

5.  Design, Synthesis and Molecular Docking Study of Novel 3-Phenyl-β-Alanine-Based Oxadiazole Analogues as Potent Carbonic Anhydrase II Inhibitors.

Authors:  Kashif Rafiq; Najeeb Ur Rehman; Sobia Ahsan Halim; Majid Khan; Ajmal Khan; Ahmed Al-Harrasi
Journal:  Molecules       Date:  2022-01-26       Impact factor: 4.411

6.  The Effect of Substituted Benzene-Sulfonamides and Clinically Licensed Drugs on the Catalytic Activity of CynT2, a Carbonic Anhydrase Crucial for Escherichia coli Life Cycle.

Authors:  Sonia Del Prete; Viviana De Luca; Silvia Bua; Alessio Nocentini; Vincenzo Carginale; Claudiu T Supuran; Clemente Capasso
Journal:  Int J Mol Sci       Date:  2020-06-11       Impact factor: 5.923

7.  Sulfonamide Inhibition Profile of the β-Carbonic Anhydrase from Malassezia restricta, An Opportunistic Pathogen Triggering Scalp Conditions.

Authors:  Sonia Del Prete; Andrea Angeli; Cynthia Ghobril; Julien Hitce; Cécile Clavaud; Xavier Marat; Claudiu T Supuran; Clemente Capasso
Journal:  Metabolites       Date:  2020-01-16

8.  Sulfonamide Inhibition Studies of an α-Carbonic Anhydrase from Schistosoma mansoni, a Platyhelminth Parasite Responsible for Schistosomiasis.

Authors:  Andrea Angeli; Mariana Pinteala; Stelian S Maier; Bogdan C Simionescu; Akram A Da'dara; Patrick J Skelly; Claudiu T Supuran
Journal:  Int J Mol Sci       Date:  2020-03-07       Impact factor: 5.923

9.  Escherichia coli γ-carbonic anhydrase: characterisation and effects of simple aromatic/heterocyclic sulphonamide inhibitors.

Authors:  Sonia Del Prete; Silvia Bua; Claudiu T Supuran; Clemente Capasso
Journal:  J Enzyme Inhib Med Chem       Date:  2020-12       Impact factor: 5.051

10.  Editorial: Keep Calm and Care for Your Microbiota: The Role of H. pylori and Microbiota in Gastric Diseases.

Authors:  Rossella Grande; Guillermo I Perez Perez
Journal:  Front Microbiol       Date:  2021-07-14       Impact factor: 5.640
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