Ruijie K Zhang1, Xiongyi Huang1, Frances H Arnold2. 1. Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, MC 210-41, Pasadena, CA 91125, United States. 2. Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, MC 210-41, Pasadena, CA 91125, United States. Electronic address: frances@cheme.caltech.edu.
Abstract
CH functionalization is an attractive strategy to construct and diversify molecules. Heme proteins, predominantly cytochromes P450, are responsible for an array of CH oxidations in biology. Recent work has coupled concepts from synthetic chemistry, computation, and natural product biosynthesis to engineer heme protein systems to deliver products with tailored oxidation patterns. Heme protein catalysis has been shown to go well beyond these native reactions and now accesses new-to-nature CH transformations, including CN and CC bond forming processes. Emerging work with these systems moves us along the ambitious path of building complexity from the ubiquitous CH bond.
CH functionalization is an attractive strategy to construct and diversify molecules. Heme proteins, predominantly cytochromes P450, are responsible for an array of n class="Disease">CH oxidations in biology. Recent work has coupled concepts from synthetic chemistry, computation, and natural product biosynthesis to engineer heme protein systems to deliver products with tailored oxidation patterns. Heme protein catalysis has been shown to go well beyond these native reactions and now accesses new-to-nature CH transformations, including CN and CC bond forming processes. Emerging work with these systems moves us along the ambitious path of building complexity from the ubiquitous CH bond.
Authors: Christopher K Prier; Ruijie K Zhang; Andrew R Buller; Sabine Brinkmann-Chen; Frances H Arnold Journal: Nat Chem Date: 2017-05-29 Impact factor: 24.427
Authors: Shengying Li; Mani Raj Chaulagain; Allison R Knauff; Larissa M Podust; John Montgomery; David H Sherman Journal: Proc Natl Acad Sci U S A Date: 2009-10-15 Impact factor: 11.205
Authors: Sean A Newmister; Kinshuk Raj Srivastava; Rosa V Espinoza; Kersti Caddell Haatveit; Yogan Khatri; Rachel M Martini; Marc Garcia-Borràs; Larissa M Podust; K N Houk; David H Sherman Journal: ACS Catal Date: 2020-11-04 Impact factor: 13.084
Authors: Laura E Russell; Mary Alexandra Schleiff; Eric Gonzalez; Aaron G Bart; Fabio Broccatelli; Jessica H Hartman; W Griffith Humphreys; Volker M Lauschke; Iain Martin; Chukwunonso Nwabufo; Bhagwat Prasad; Emily E Scott; Matthew Segall; Ryan Takahashi; Mitchell E Taub; Jasleen K Sodhi Journal: Drug Metab Rev Date: 2020-05-26 Impact factor: 4.518
Authors: Guangde Jiang; Yi Zhang; Magan M Powell; Sarah M Hylton; Nicholas W Hiller; Rosemary Loria; Yousong Ding Journal: Chembiochem Date: 2019-03-27 Impact factor: 3.164