Literature DB >> 3033533

The hydrolysis of glycerophosphocholine by rat brain microsomes: activation and inhibition.

S Spanner, G B Ansell.   

Abstract

Experiments with glycerophosphocholine phosphodiesterase (GPC diesterase, EC 3.1.4.2.) in rat brain microsomes suggest that, although its activity is inhibited by low concentrations of calmidazolium, its dependence on Ca2+ ions is not modulated by calmodulin. The activity of glycerophosphocholine choline phosphodiesterase (choline phosphohydrolase, EC 3.1.4.38) was much lower than that of the GPC diesterase. A relatively inexpensive method for the preparation of sn-glycero-3-phospho [Me-14C]choline is described.

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Year:  1987        PMID： 3033533     DOI： 10.1007/BF00979538

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  18 in total

1.  [The water soluble esters of choline; glycerylphosphorylcholine].

Authors:  M DIAMENT; E KAHANE; J LEVY
Journal:  C R Hebd Seances Acad Sci       Date:  1952-11-03

2.  A novel pathway for phosphatidylcholine catabolism in rat brain homogenates.

Authors:  R M Abra; P J Quinn
Journal:  Biochim Biophys Acta       Date:  1975-03-24

3.  Inhibition of calmodulin-dependent and independent cardiac sarcoplasmic reticulum activities by R24571.

Authors:  C F Louis; J Turnquist; B Jarvis
Journal:  Cell Calcium       Date:  1983-04       Impact factor: 6.817

4.  R 24571: a new powerful inhibitor of red blood cell Ca++-transport ATPase and of calmodulin-regulated functions.

Authors:  K Gietzen; A Wüthrich; H Bader
Journal:  Biochem Biophys Res Commun       Date:  1981-07-30       Impact factor: 3.575

5.  A hypothesis: noncyclic phosphodiesters may play a role in membrane control.

Authors:  C T Burt; H J Ribolow
Journal:  Biochem Med       Date:  1984-02

Review 6.  Interaction of drugs with calmodulin. Biochemical, pharmacological and clinical implications.

Authors:  B Weiss; W C Prozialeck; T L Wallace
Journal:  Biochem Pharmacol       Date:  1982-07-01       Impact factor: 5.858

7.  Activation of glycerophosphocholine phosphodiesterase in rat forebrain by Ca2+.

Authors:  S Spanner; G B Ansell
Journal:  Biochem J       Date:  1982-12-15       Impact factor: 3.857

8.  Defective synthesis of glycerophosphorylcholine in murine muscular dystrophy; the primary molecular lesion?

Authors:  J P Infante
Journal:  FEBS Lett       Date:  1985-07-08       Impact factor: 4.124

9.  Structural similarities between the Ca2+-dependent regulatory proteins of 3':5'-cyclic nucleotide phosphodiesterase and actomyosin ATPase.

Authors:  D M Watterson; W G Harrelson; P M Keller; F Sharief; T C Vanaman
Journal:  J Biol Chem       Date:  1976-08-10       Impact factor: 5.157

10.  The effects of various incubation temperatures, particulate isolation, and possible role of calmodulin on the activity of the base exchange enzymes of rat brain.

Authors:  A G Buchanan; J N Kanfer
Journal:  J Neurochem       Date:  1980-10       Impact factor: 5.372
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  9 in total

1.  Characterization of a Zn(2+)-requiring glycerophosphocholine cholinephosphodiesterase possessing p-nitrophenylphosphocholine phosphodiesterase activity.

Authors:  D E Sok; M R Kim
Journal:  Biochem J       Date:  1992-09-01       Impact factor: 3.857

2.  An unusual phosphodiesterase activity towards p-nitrophenylphosphorylcholine present in rat brain membranes.

Authors:  J N Kanfer; D McCartney
Journal:  Neurochem Res       Date:  1990-10       Impact factor: 3.996

3.  Tight connection between choline transport and phosphatidylcholine synthesis in MDCK cells.

Authors:  P Zlatkine; C Leroy; G Moll; C Le Grimellec
Journal:  Biochem J       Date:  1996-05-01       Impact factor: 3.857

4.  Developmental and regional quantitation of glycerophosphorylcholine phosphodiesterase activities in rat brain.

Authors:  J N Kanfer; D G McCartney
Journal:  Neurochem Res       Date:  1988-09       Impact factor: 3.996

5.  Accumulation of glycerophosphocholine (GPC) by renal cells: osmotic regulation of GPC:choline phosphodiesterase.

Authors:  K Zablocki; S P Miller; A Garcia-Perez; M B Burg
Journal:  Proc Natl Acad Sci U S A       Date:  1991-09-01       Impact factor: 11.205

6.  Identification and characterization of plant glycerophosphodiester phosphodiesterase.

Authors:  Benoît Van Der Rest; Norbert Rolland; Anne-Marie Boisson; Myriam Ferro; Richard Bligny; Roland Douce
Journal:  Biochem J       Date:  2004-05-01       Impact factor: 3.857

7.  Purification and properties of a glycerophosphocholine phosphodiesterase from bovine brain myelin.

Authors:  J Yuan; J N Kanfer
Journal:  Neurochem Res       Date:  1994-01       Impact factor: 3.996

8.  Involvement of both a Zn2+ site and an anionic binding site in the selective inhibition of a Zn(2+)-glycerophosphocholine cholinephosphodiesterase by thiols and tellurites.

Authors:  D E Sok; M R Kim
Journal:  Neurochem Res       Date:  1995-02       Impact factor: 3.996

9.  Multiple forms of the enzyme glycerophosphodiesterase are present in human brain.

Authors:  B M Ross; A L Sherwin; S J Kish
Journal:  Lipids       Date:  1995-12       Impact factor: 1.880
  9 in total

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