Literature DB >> 1963926

An unusual phosphodiesterase activity towards p-nitrophenylphosphorylcholine present in rat brain membranes.

J N Kanfer1, D McCartney.   

Abstract

A phosphodiesterase activity present in rat brain membranes has been examined utilizing p-nitrophenylphosphorylcholine as the substrate. This enzyme activity has a pH optimum of 8.5, is stimulated by a variety of free fatty acids, requires either Zn+2 or Ca+2 and is relatively stable to heating at 75 degrees C for 7.5 minutes. These properties appear to distinguish this particular activity from those previously reported for alkaline phosphatase, nonspecific phosphodiesterase, phosphodiesterases I and II, lecithinase, and sphingomyelinase.

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Year:  1990        PMID： 1963926     DOI： 10.1007/bf00965744

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  22 in total

1.  The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation.

Authors:  E G GRAY; V P WHITTAKER
Journal:  J Anat       Date:  1962-01       Impact factor: 2.610

2.  Magnesium-dependent sphingomyelinase.

Authors:  S Gatt
Journal:  Biochem Biophys Res Commun       Date:  1976-01-12       Impact factor: 3.575

3.  Phospholipase C assay using p-nitrophenylphosphoryl-choline together with sorbitol and its application to studying the metal and detergent requirement of the enzyme.

Authors:  S Kurioka; M Matsuda
Journal:  Anal Biochem       Date:  1976-09       Impact factor: 3.365

4.  The hydrolysis of glycerophosphocholine by rat brain microsomes: activation and inhibition.

Authors:  S Spanner; G B Ansell
Journal:  Neurochem Res       Date:  1987-02       Impact factor: 3.996

5.  Isolation and properties of a phosphatidylcholine-specific phospholipase C from bull seminal plasma.

Authors:  R G Sheikhnejad; P N Srivastava
Journal:  J Biol Chem       Date:  1986-06-05       Impact factor: 5.157

6.  Intracellular localization of phosphodiesterases I and II in rat liver.

Authors:  M Erecińska; H Sierakowska; D Shugar
Journal:  Eur J Biochem       Date:  1969-12

7.  Synthesis of p-nitrophenylphosphorylcholine and the hydrolysis with phospholipase C.

Authors:  S Kurioka
Journal:  J Biochem       Date:  1968-05       Impact factor: 3.387

8.  Fatty acid activation and temperature perturbation of rat brain microsomal phospholipase D.

Authors:  R Chalifour; J N Kanfer
Journal:  J Neurochem       Date:  1982-08       Impact factor: 5.372

9.  Properties of phospholipase C isolated from rat liver lysosomes.

Authors:  Y Matsuzawa; K Y Hostetler
Journal:  J Biol Chem       Date:  1980-01-25       Impact factor: 5.157

10.  Phosphatidylcholine and 4-methylumbelliferyl phosphorylcholine hydrolysis by purified placental sphingomyelinase.

Authors:  S J Freeman; P Shankaran; L S Wolfe; J W Callahan
Journal:  Can J Biochem Cell Biol       Date:  1985-04
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  4 in total

1.  Characterization of a Zn(2+)-requiring glycerophosphocholine cholinephosphodiesterase possessing p-nitrophenylphosphocholine phosphodiesterase activity.

Authors:  D E Sok; M R Kim
Journal:  Biochem J       Date:  1992-09-01       Impact factor: 3.857

2.  Interaction of divalent metal ions with Zn(2+)-glycerophosphocholine cholinephosphodiesterase from ox brain.

Authors:  K J Lee; M R Kim; Y B Kim; P K Myung; D E Sok
Journal:  Neurochem Res       Date:  1997-12       Impact factor: 3.996

3.  Purification and characterization of lysophospholipase C from pig brain.

Authors:  Nguyen Dang Hung; Mee Ree Kim; Dai-Eun Sok
Journal:  Neurochem Res       Date:  2009-07-09       Impact factor: 3.996

4.  Magnesium sulfate treatment for juvenile ferrets following induction of hydrocephalus with kaolin.

Authors:  Domenico L Di Curzio; Emily Turner-Brannen; Xiaoyan Mao; Marc R Del Bigio
Journal:  Fluids Barriers CNS       Date:  2016-04-27
  4 in total

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