| Literature DB >> 30332561 |
Perry V Halushka1,2, Andrew J Goodwin3, Marc K Halushka4.
Abstract
Cardiovascular diseases exist across all developed countries. Biomarkers that can predict or diagnose diseases early in their pathogeneses can reduce their morbidity and mortality in afflicted individuals. microRNAs are small regulatory RNAs that modulate translation and have been identified as potential fluid-based biomarkers across numerous maladies. We describe the current state of cardiovascular disease biomarkers across a range of diseases, including myocardial infarction, acute coronary syndrome, myocarditis, hypertension, heart failure, heart transplantation, aortic stenosis, diabetic cardiomyopathy, atrial fibrillation, and sepsis. We present the current understanding of microRNAs as possible biomarkers in these categories and where their best opportunities exist to enter clinical practice.Entities:
Keywords: aortic stenosis; biomarkers; cardiovascular disease; hypertension; microRNAs; sepsis
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Year: 2018 PMID： 30332561 PMCID： PMC6442682 DOI： 10.1146/annurev-pathmechdis-012418-012827
Source DB: PubMed Journal: Annu Rev Pathol ISSN： 1553-4006 Impact factor: 23.472