| Literature DB >> 24263017 |
Gerald J Berry1, Margaret M Burke, Claus Andersen, Patrick Bruneval, Marny Fedrigo, Michael C Fishbein, Martin Goddard, Elizabeth H Hammond, Ornella Leone, Charles Marboe, Dylan Miller, Desley Neil, Doris Rassl, Monica P Revelo, Alexandra Rice, E Rene Rodriguez, Susan Stewart, Carmela D Tan, Gayle L Winters, Lori West, Mandeep R Mehra, Annalisa Angelini.
Abstract
During the last 25 years, antibody-mediated rejection of the cardiac allograft has evolved from a relatively obscure concept to a recognized clinical complication in the management of heart transplant patients. Herein we report the consensus findings from a series of meetings held between 2010-2012 to develop a Working Formulation for the pathologic diagnosis, grading, and reporting of cardiac antibody-mediated rejection. The diagnostic criteria for its morphologic and immunopathologic components are enumerated, illustrated, and described in detail. Numerous challenges and unresolved clinical, immunologic, and pathologic questions remain to which a Working Formulation may facilitate answers.Entities:
Keywords: activated mononuclear cells; antibody mediated rejection; complement; heart; immunofluorescence; immunohistochemistry; intravascular
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Year: 2013 PMID： 24263017 DOI： 10.1016/j.healun.2013.08.011
Source DB: PubMed Journal: J Heart Lung Transplant ISSN： 1053-2498 Impact factor: 10.247