Literature DB >> 3032612

In vitro activity of LY146032 (daptomycin) against selected aerobic bacteria.

J H Jorgensen, L A Maher, J S Redding.   

Abstract

The in vitro activity of the new lipopeptide antibiotic LY146032 was generally four-fold greater (MIC 90 less than or equal to 0.5 microgram/ml) than that of vancomycin against methicillin-susceptible or methicillin-resistant Staphylococcus aureus and coagulase-negative species of Staphylococcus. Enterococci, Streptococcus bovis, group B and viridans streptococci, and Corynebacterium group J-K isolates were inhibited by less than or equal to 4 micrograms/ml of LY146032, which represented activity equivalent to or greater than that of vancomycin. Unlike vancomycin, LY146032 was bactericidal for Enterococcus faecalis, Enterococcus faecium and Listeria monocytogenes. Due to its bactericidal properties LY146032 appeared to represent an improvement over vancomycin and teicoplanin.

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Year:  1987        PMID： 3032612     DOI： 10.1007/BF02097209

Source DB:  PubMed          Journal:  Eur J Clin Microbiol        ISSN： 0722-2211            Impact factor:   3.267


  9 in total

1.  Characterization and identification of 95 diphtheroid (group JK) cultures isolated from clinical specimens.

Authors:  P S Riley; D G Hollis; G B Utter; R E Weaver; C N Baker
Journal:  J Clin Microbiol       Date:  1979-03       Impact factor: 5.948

2.  Method of reliable determination of minimal lethal antibiotic concentrations.

Authors:  R D Pearson; R T Steigbigel; H T Davis; S W Chapman
Journal:  Antimicrob Agents Chemother       Date:  1980-11       Impact factor: 5.191

3.  Treatment of infections due to methicillin-resistant Staphylococcus aureus.

Authors:  C Watanakunakorn
Journal:  Ann Intern Med       Date:  1982-09       Impact factor: 25.391

4.  The emergence of methicillin-resistant Staphylococcus aureus infections in United States hospitals. Possible role of the house staff-patient transfer circuit.

Authors:  R W Haley; A W Hightower; R F Khabbaz; C Thornsberry; W J Martone; J R Allen; J M Hughes
Journal:  Ann Intern Med       Date:  1982-09       Impact factor: 25.391

5.  Successful use of broth microdilution in susceptibility tests for methicillin-resistant (heteroresistant) staphylococci.

Authors:  C Thornsberry; L K McDougal
Journal:  J Clin Microbiol       Date:  1983-11       Impact factor: 5.948

6.  Staphylococcus epidermidis causing prosthetic valve endocarditis: microbiologic and clinical observations as guides to therapy.

Authors:  A W Karchmer; G L Archer; W E Dismukes
Journal:  Ann Intern Med       Date:  1983-04       Impact factor: 25.391

7.  The emergence of coryneform bacteria as a cause of nosocomial infections in compromised hosts.

Authors:  V M Young; W F Meyers; M R Moody; S C Schimpff
Journal:  Am J Med       Date:  1981-03       Impact factor: 4.965

8.  Activity of teicoplanin compared with vancomycin alone, and combined with gentamicin, against penicillin tolerant viridans streptococci and enterococci causing endocarditis.

Authors:  D C Shanson; M Tadayon
Journal:  J Hosp Infect       Date:  1986-03       Impact factor: 3.926

9.  Synergism of vancomycin-gentamicin and vancomycin-streptomycin against enterococci.

Authors:  C Watanakunakorn; C Bakie
Journal:  Antimicrob Agents Chemother       Date:  1973-08       Impact factor: 5.191
  9 in total
  14 in total

1.  Investigation of the early killing of Staphylococcus aureus by daptomycin by using an in vitro pharmacodynamic model.

Authors:  K Vance-Bryan; T A Larson; J C Rotschafer; J P Toscano
Journal:  Antimicrob Agents Chemother       Date:  1992-10       Impact factor: 5.191

2.  Assessment of two commercial susceptibility test methods for determination of daptomycin MICs.

Authors:  James H Jorgensen; Sharon A Crawford
Journal:  J Clin Microbiol       Date:  2006-06       Impact factor: 5.948

3.  Correlation of penicillin-induced lysis of Enterococcus faecium with saturation of essential penicillin-binding proteins and release of lipoteichoic acid.

Authors:  S al-Obeid; L Gutmann; R Williamson
Journal:  Antimicrob Agents Chemother       Date:  1990-10       Impact factor: 5.191

4.  Problems with the disk diffusion test for detection of vancomycin resistance in enterococci.

Authors:  J M Swenson; B C Hill; C Thornsberry
Journal:  J Clin Microbiol       Date:  1989-09       Impact factor: 5.948

5.  Staphylococcus aureus ventriculitis treated with single-dose intraventricular vancomycin or daptomycin (LY146032): bacterial and antibiotic kinetics in hydrocephalic rabbits.

Authors:  C S Haworth; M W Sobieski; W M Scheld; T S Park
Journal:  Antimicrob Agents Chemother       Date:  1990-02       Impact factor: 5.191

6.  Use of multivariate analysis to compare antimicrobial agents on the basis of in vitro activity data.

Authors:  J M Hernández; P Conforti
Journal:  Antimicrob Agents Chemother       Date:  1994-02       Impact factor: 5.191

7.  Activity of daptomycin against recent North American isolates of Streptococcus pneumoniae.

Authors:  M I Restrepo; J A Velez; M L McElmeel; C G Whitney; J H Jorgensen
Journal:  Antimicrob Agents Chemother       Date:  2003-09       Impact factor: 5.191

8.  Antibacterial activity of the new glycopeptide antibiotic SKF104662.

Authors:  J H Jorgensen; J S Redding; L A Maher
Journal:  Antimicrob Agents Chemother       Date:  1989-04       Impact factor: 5.191

9.  In vitro activity of daptomycin against vancomycin-resistant enterococci of various Van types and comparison of susceptibility testing methods.

Authors:  James H Jorgensen; Sharon A Crawford; Cynthia C Kelly; Jan E Patterson
Journal:  Antimicrob Agents Chemother       Date:  2003-12       Impact factor: 5.191

10.  Early stages of in vitro killing curve of LY146032 and vancomycin for Staphylococcus aureus.

Authors:  J P Flandrois; G Fardel; G Carret
Journal:  Antimicrob Agents Chemother       Date:  1988-04       Impact factor: 5.191
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