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Literature DB >> 303228

Classification of alpha1-antitrypsin (Pi) phenotypes by isoelectrofocusing. Distinction of six subtypes of the PiM phenotype.

Abstract

Pi phenotypes have been determined by isoelectrofocusing in a sample of 538 healthy individuals from Southern Germany. Further subdivision of the common PiM phenotype is described. A procedure for the delineation of six common subtypes is presented. It is assumed that the six subtypes are determined by three alleles which are provisionally called PiMa, PiMb, and PiMc. Their frequencies in this sample were 0.75, 0.06, and 0.15, respectively.

Entities: Gene

Mesh：

Substances：
alpha 1-Antitrypsin

Year: 1977 PMID： 303228 DOI： 10.1007/bf00402159

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

14 in total

1. The electrophoretic α1-globulin pattern of serum in α1-antitrypsin deficiency. 1963.

Authors: Carl-Bertil Laurell; Sten Eriksson
Journal: COPD Date: 2013-03 Impact factor: 2.409

2. Inherited variants of alpha1-antitrypsin: a new allele PiN.

Authors: D W Cox; L Celhoffer
Journal: Can J Genet Cytol Date: 1974-06

3. Analysis of plasma 1 -antitrypsin variants and their microheterogeneity.

Authors: C B Laurell; U Persson
Journal: Biochim Biophys Acta Date: 1973-06-15

Review 4. The Pi system-inherited variants of serum alpha 1-antitrypsin.

Authors: M K Fagerhol; C B Laurell
Journal: Prog Med Genet Date: 1970

5. Investigations on the population genetics of the alpha-1-antitrypsin polymorphism.

Authors: G Kellermann; H Walter
Journal: Humangenetik Date: 1970-09-17

Review 6. Alpha-1-antitrypsin: physiology, genetics and pathology.

Authors: F Kueppers
Journal: Humangenetik Date: 1971

7. A new method for determination of alpha-1-antitrypsin phenotypes using isoelectric focusing on polyacrylamide gel slabs.

Authors: R C Allen; R A Harley; R C Talamo
Journal: Am J Clin Pathol Date: 1974-12 Impact factor: 2.493

8. [Study of genetic variants of alpha 1-antitrypsin in bidimensional immuno-electrofocusing].

Authors: J Lebas; A Hayem; J P Martin
Journal: C R Acad Hebd Seances Acad Sci D Date: 1974-04-29

9. Alpha 1 antitrypsin M1: a new common genetically determined variant.

Authors: F Kueppers
Journal: Am J Hum Genet Date: 1976-07 Impact factor: 11.025

10. alpha1-antitrypsin: common subtypes of Pi M.

Authors: R R Frants; A W Eriksson
Journal: Hum Hered Date: 1976 Impact factor: 0.444

16 in total

1. Linkage studies on the human Pi, Gm, GLO, and HLA genes.

Authors: K Bender; C R Müller; A Schmidt; U Strohmaier; T F Wienker
Journal: Hum Genet Date: 1979-06-19 Impact factor: 4.132

2. Characterization of the gene and protein of the common alpha 1-antitrypsin normal M2 allele.

Authors: T Nukiwa; M L Brantly; F Ogushi; G A Fells; R G Crystal
Journal: Am J Hum Genet Date: 1988-09 Impact factor: 11.025

3. Alpha1-antitrypsin: further genetic heterogeneity revealed by isoelectric focusing.

Authors: F Kueppers; M J Christopherson
Journal: Am J Hum Genet Date: 1978-07 Impact factor: 11.025

4. Structural difference between the normal PiM1 and the common PiM2 variant of human alpha 1-antitrypsin.

Authors: A Yoshida; J C Taylor; W G van den Brock
Journal: Am J Hum Genet Date: 1979-09 Impact factor: 11.025

5. Characterization of alpha-1-antitrypsin by isoelectric focusing on an ultrathin polyacrylamide gel layer. An economic high-resolution system for determining PiM subtypes.

Authors: G Massi; A Fabiano; D Ragusa; P Auconi
Journal: Hum Genet Date: 1979 Impact factor: 4.132