Literature DB >> 30320091

Malignant Transformation of a Multi-Operated Divided Nevus of the Eyelids.

Stéphanie Lemaître1,2,3, Sophie Gardrat1,4, Anne Vincent-Salomon1,4, Olivier Galatoire5, Christine Lévy-Gabriel1,3, Laurence Desjardins1,3.   

Abstract

A woman in her early fifties had regular follow-up for a medium-sized divided nevus of the eyelids which had undergone several surgical excisions during childhood for functional and esthetic reasons. Malignant transformation of the nevus occurred in the inferior eyelid, with the appearance of a new pigmented flat lesion. Histology showed in situ melanoma, and an NRAS activating mutation was found. A full-thickness excision of the inferior eyelid was performed, followed by reconstruction. Local recurrence of the melanoma occurred 1 year after surgery. Lifelong follow-up of divided nevi of the eyelids is recommended, even if very few cases of malignant transformation have been reported so far.

Entities:  

Keywords:  Divided nevus; Eyelid; Kissing nevus; Melanoma

Year:  2017        PMID： 30320091      PMCID： PMC6167659          DOI： 10.1159/000479069

Source DB:  PubMed          Journal:  Ocul Oncol Pathol        ISSN： 2296-4657


  13 in total

1.  Risk of malignant transformation of congenital melanocytic nevi: a retrospective nationwide study from The Netherlands.

Authors:  Laura H Zaal; Wolter J Mooi; Helen Klip; Chantal M A M van der Horst
Journal:  Plast Reconstr Surg       Date:  2005-12       Impact factor: 4.730

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Authors:  Sven Krengel; Alon Scope; Stephen W Dusza; Reinhard Vonthein; Ashfaq A Marghoob
Journal:  J Am Acad Dermatol       Date:  2012-09-13       Impact factor: 11.527

4.  Malignant transformation of kissing nevus- a rare entity.

Authors:  R Kharel Sitaula; S Batta; G B Shrestha; J K Shrestha
Journal:  Nepal J Ophthalmol       Date:  2012 Jul-Dec

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Authors:  S Morax; P Dhermy; S Sangare
Journal:  J Fr Ophtalmol       Date:  1982       Impact factor: 0.818

Review 6.  The shifting paradigm in the management of giant congenital melanocytic nevi: review and clinical applications.

Authors:  Ehud Arad; Ronald M Zuker
Journal:  Plast Reconstr Surg       Date:  2014-02       Impact factor: 4.730

7.  High frequency of BRAF mutations in nevi.

Authors:  Pamela M Pollock; Ursula L Harper; Katherine S Hansen; Laura M Yudt; Mitchell Stark; Christiane M Robbins; Tracy Y Moses; Galen Hostetter; Urs Wagner; John Kakareka; Ghadi Salem; Tom Pohida; Peter Heenan; Paul Duray; Olli Kallioniemi; Nicholas K Hayward; Jeffrey M Trent; Paul S Meltzer
Journal:  Nat Genet       Date:  2002-11-25       Impact factor: 38.330

8.  Molecular nevogenesis.

Authors:  Andrew L Ross; Margaret I Sanchez; James M Grichnik
Journal:  Dermatol Res Pract       Date:  2011-04-06

9.  Kissing naevus arising from neural crest cells presenting as upper and the lower lid mass.

Authors:  Gian Chand Rajput; Deepti Mahajan; Kulbhushan Prakash Chaudhary; V Deewana
Journal:  J Neurosci Rural Pract       Date:  2015 Jul-Sep

10.  Staged Surgery with Total Excision and Lamellar Reconstructive for Medium-sized Divided Nevus of the Eyelids.

Authors:  Rong Lu; Qian Li; Yadan Quan; Kang Li; Jinling Liu
Journal:  Plast Reconstr Surg Glob Open       Date:  2015-07-08
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