Literature DB >> 24469170

The shifting paradigm in the management of giant congenital melanocytic nevi: review and clinical applications.

Ehud Arad1, Ronald M Zuker.   

Abstract

SUMMARY: Congenital melanocytic nevi remain a subject of controversy with respect to risk of malignant transformation and recommended management. Recent studies indicate a lower malignant risk (0.7 to 2.9 percent) than had previously been estimated. Surgery has not been proven to reduce malignant risk or improve quality of life, and may result in undesirable aesthetic and functional outcomes. In this article, the authors review key controversial issues in the management of congenital melanocytic nevi and re-evaluate indications for surgical treatment. An updated review of controversial topics in the management of congenital melanocytic nevi is presented, and clinical applications are demonstrated through clinical cases. Updates regarding the risks and outcomes of congenital melanocytic nevi patients open a renewed debate with respect to the indications for surgery as well as the extent of surgery that may be suitable. Treatment should be tailored to achieve optimal aesthetic results whereby complete nevus excision is not the goal. As such, nonsurgical management and incomplete nevus excision should be integrated as legitimate parts of any treatment algorithm.

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Year:  2014        PMID: 24469170     DOI: 10.1097/01.prs.0000436852.32527.8a

Source DB:  PubMed          Journal:  Plast Reconstr Surg        ISSN: 0032-1052            Impact factor:   4.730


  12 in total

1.  A case report of the first application of culture epithelial autograft (JACE®) for giant congenital melanocytic nevus after its approval in Japan.

Authors:  Naoki Morimoto; Natsuko Kakudo; Ayako Kako; Keiko Nishimura; Toshihito Mitsui; Ryohei Miyake; Atsuyuki Kuro; Masakatsu Hihara; Kenji Kusumoto
Journal:  J Artif Organs       Date:  2017-11-17       Impact factor: 1.731

2.  A large-scale collection of giant congenital melanocytic nevi: Clinical and histopathological characteristics.

Authors:  Min Wu; Qingxiong Yu; Bowen Gao; Lingling Sheng; Qingfeng Li; Feng Xie
Journal:  Exp Ther Med       Date:  2019-11-14       Impact factor: 2.447

3.  Malignant Transformation of a Multi-Operated Divided Nevus of the Eyelids.

Authors:  Stéphanie Lemaître; Sophie Gardrat; Anne Vincent-Salomon; Olivier Galatoire; Christine Lévy-Gabriel; Laurence Desjardins
Journal:  Ocul Oncol Pathol       Date:  2017-09-02

4.  The Alteration of the Epidermal Basement Membrane Complex of Human Nevus Tissue and Keratinocyte Attachment after High Hydrostatic Pressurization.

Authors:  Naoki Morimoto; Chizuru Jinno; Atsushi Mahara; Michiharu Sakamoto; Natsuko Kakudo; Masukazu Inoie; Toshia Fujisato; Shigehiko Suzuki; Kenji Kusumoto; Tetsuji Yamaoka
Journal:  Biomed Res Int       Date:  2016-09-26       Impact factor: 3.411

5.  Melanin pigments in the melanocytic nevus regress spontaneously after inactivation by high hydrostatic pressure.

Authors:  Michiharu Sakamoto; Naoki Morimoto; Chizuru Jinno; Atsushi Mahara; Shuichi Ogino; Shigehiko Suzuki; Kenji Kusumoto; Tetsuji Yamaoka
Journal:  PLoS One       Date:  2017-11-01       Impact factor: 3.240

6.  Simplified management of a giant forehead congenital nevus allows for early reconstruction.

Authors:  Moris Topaz; Michael Gurevich; Itamar Ashkenazi
Journal:  BMJ Case Rep       Date:  2020-07-13

7.  Inactivated Nevus Tissue with High Hydrostatic Pressure Treatment Used as a Dermal Substitute after a 28-Day Cryopreservation Period.

Authors:  Yoshitaka Matsuura; Michiharu Sakamoto; Shuichi Ogino; Jun Arata; Naoki Morimoto
Journal:  Biomed Res Int       Date:  2021-02-24       Impact factor: 3.411

8.  A Case of Giant Congenital Melanocytic Nevus Treated with Combination Therapy of Autologous Mesh-skin Grafts and Cultured Epithelial Autografts.

Authors:  Seongwang Im; Hiroki Yamanaka; Itaru Tsuge; Motoki Katsube; Michiharu Sakamoto; Naoki Morimoto
Journal:  Plast Reconstr Surg Glob Open       Date:  2021-06-07

9.  Giant Congenital Melanocytic Nevus in a Chinese Newborn.

Authors:  Weizhao Lin; Yixuan Zhou; Ruiman Li
Journal:  Clin Cosmet Investig Dermatol       Date:  2021-05-26

10.  An Exploratory Clinical Trial of a Novel Treatment for Giant Congenital Melanocytic Nevi Combining Inactivated Autologous Nevus Tissue by High Hydrostatic Pressure and a Cultured Epidermal Autograft: Study Protocol.

Authors:  Naoki Morimoto; Chizuru Jinno; Michiharu Sakamoto; Natsuko Kakudo; Tetsuji Yamaoka; Kenji Kusumoto
Journal:  JMIR Res Protoc       Date:  2016-08-11
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