| Literature DB >> 30299256 |
Bram Cerulus1,2, Abbas Jariani1,2, Gemma Perez-Samper1,2, Lieselotte Vermeersch1,2, Julian Mj Pietsch3, Matthew M Crane3,4, Aaron M New1,2, Brigida Gallone1,2,5,6, Miguel Roncoroni1,2, Maria C Dzialo1,2, Sander K Govers1,2, Jhana O Hendrickx1,2, Eva Galle1,2, Maarten Coomans1,2, Pieter Berden1,2, Sara Verbandt1,2, Peter S Swain3, Kevin J Verstrepen1,2.
Abstract
Cells constantly adapt to environmental fluctuations. These physiological changes require time and therefore cause a lag phase during which the cells do not function optimally. Interestingly, past exposure to an environmental condition can shorten the time needed to adapt when the condition re-occurs, even in daughter cells that never directly encountered the initial condition. Here, we use the molecular toolbox of Saccharomyces cerevisiae to systematically unravel the molecular mechanism underlying such history-dependent behavior in transitions between glucose and maltose. In contrast to previous hypotheses, the behavior does not depend on persistence of proteins involved in metabolism of a specific sugar. Instead, presence of glucose induces a gradual decline in the cells' ability to activate respiration, which is needed to metabolize alternative carbon sources. These results reveal how trans-generational transitions in central carbon metabolism generate history-dependent behavior in yeast, and provide a mechanistic framework for similar phenomena in other cell types.Entities:
Keywords: S. cerevisiae; cellular memory; computational biology; gene regulation; glucose repression; infectious disease; lag phase; metabolic shift; microbiology; single-cell analysis; systems biology
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Year: 2018 PMID： 30299256 PMCID： PMC6211830 DOI： 10.7554/eLife.39234
Source DB: PubMed Journal: Elife ISSN： 2050-084X Impact factor: 8.140