Hendrik Mattern1, Alessandro Sciarra1, Falk Lüsebrink1, Julio Acosta-Cabronero2,3, Oliver Speck1,3,4,5. 1. Department of Biomedical Magnetic Resonance, Institute for Physics, Otto-von-Guericke-University, Magdeburg, Germany. 2. Wellcome Centre for Human Neuroimaging, Institute of Neurology, University College London, London, United Kingdom. 3. German Center for Neurodegenerative Diseases, Magdeburg, Germany. 4. Center for Behavioral Brain Sciences, Magdeburg, Germany. 5. Leibniz Institute for Neurobiology, Magdeburg, Germany.
Abstract
PURPOSE: Recent literature has shown the potential of high-resolution quantitative susceptibility mapping (QSM) with ultra-high field MRI for imaging the anatomy, the vasculature, and investigating their magnetostatic properties. Higher spatial resolutions, however, translate to longer scans resulting, therefore, in higher vulnerability to, and likelihood of, subject movement. We propose a gradient-recalled echo sequence with prospective motion correction (PMC) to address such limitation. METHODS: Data from 4 subjects were acquired at 7T. The effect of small and large motion on QSM with and without PMC was assessed qualitatively and quantitatively. Full brain QSM and QSM-based venograms with up to 0.33 mm isotropic voxel size were reconstructed. RESULTS: With PMC, motion artifacts in QSM and QSM-based venograms were largely eliminated, enabling-in both large- and small-amplitude motion regimes-accurate depiction of the cortex, vasculature, and other small anatomical structures that are often blurred as a result of head movement or indiscernible at lower image resolutions. Quantitative analyses demonstrated that uncorrected motion could bias regional susceptibility distributions, a trend that was greatly reduced with PMC. CONCLUSION: Qualitatively, PMC prevented image degradation because of motion artifacts, providing highly detailed QSM images and venograms. Quantitatively, PMC increased the reproducibility of susceptibility measures.
PURPOSE: Recent literature has shown the potential of high-resolution quantitative susceptibility mapping (QSM) with ultra-high field MRI for imaging the anatomy, the vasculature, and investigating their magnetostatic properties. Higher spatial resolutions, however, translate to longer scans resulting, therefore, in higher vulnerability to, and likelihood of, subject movement. We propose a gradient-recalled echo sequence with prospective motion correction (PMC) to address such limitation. METHODS: Data from 4 subjects were acquired at 7T. The effect of small and large motion on QSM with and without PMC was assessed qualitatively and quantitatively. Full brain QSM and QSM-based venograms with up to 0.33 mm isotropic voxel size were reconstructed. RESULTS: With PMC, motion artifacts in QSM and QSM-based venograms were largely eliminated, enabling-in both large- and small-amplitude motion regimes-accurate depiction of the cortex, vasculature, and other small anatomical structures that are often blurred as a result of head movement or indiscernible at lower image resolutions. Quantitative analyses demonstrated that uncorrected motion could bias regional susceptibility distributions, a trend that was greatly reduced with PMC. CONCLUSION: Qualitatively, PMC prevented image degradation because of motion artifacts, providing highly detailed QSM images and venograms. Quantitatively, PMC increased the reproducibility of susceptibility measures.
Authors: Phillip DiGiacomo; Julian Maclaren; Murat Aksoy; Elizabeth Tong; Mackenzie Carlson; Bryan Lanzman; Syed Hashmi; Ronald Watkins; Jarrett Rosenberg; Brian Burns; Timothy W Skloss; Dan Rettmann; Brian Rutt; Roland Bammer; Michael Zeineh Journal: Magn Reson Med Date: 2020-02-20 Impact factor: 4.668
Authors: Falk Lüsebrink; Hendrik Mattern; Renat Yakupov; Julio Acosta-Cabronero; Mohammad Ashtarayeh; Steffen Oeltze-Jafra; Oliver Speck Journal: Sci Data Date: 2021-05-25 Impact factor: 6.444
Authors: Harry Duckworth; Adriana Azor; Nikolaus Wischmann; Karl A Zimmerman; Ilaria Tanini; David J Sharp; Mazdak Ghajari Journal: Front Bioeng Biotechnol Date: 2022-04-20
Authors: Saskia Bollmann; Hendrik Mattern; Michaël Bernier; Simon D Robinson; Daniel Park; Oliver Speck; Jonathan R Polimeni Journal: Elife Date: 2022-04-29 Impact factor: 8.713