Literature DB >> 30295029

Structural Studies of Amyloid Fibrils by Paramagnetic Solid-State Nuclear Magnetic Resonance Spectroscopy.

Theint Theint1, Yongjie Xia1, Philippe S Nadaud1, Dwaipayan Mukhopadhyay1, Charles D Schwieters2, Krystyna Surewicz3, Witold K Surewicz3, Christopher P Jaroniec1.   

Abstract

Application of paramagnetic solid-state NMR to amyloids is demonstrated, using Y145Stop human prion protein modified with nitroxide spin-label or EDTA-Cu2+ tags as a model. By using sample preparation protocols based on seeding with preformed fibrils, we show that paramagnetic protein analogs can be induced into adopting the wild-type amyloid structure. Measurements of residue-specific intramolecular and intermolecular paramagnetic relaxation enhancements enable determination of protein fold within the fibril core and protofilament assembly. These methods are expected to be widely applicable to other amyloids and protein assemblies.

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Year:  2018        PMID： 30295029      PMCID： PMC6193843          DOI： 10.1021/jacs.8b06758

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  45 in total

1.  Nucleation-dependent conformational conversion of the Y145Stop variant of human prion protein: structural clues for prion propagation.

Authors:  Bishwajit Kundu; Nilesh R Maiti; Eric M Jones; Krystyna A Surewicz; David L Vanik; Witold K Surewicz
Journal:  Proc Natl Acad Sci U S A       Date:  2003-09-30       Impact factor: 11.205

2.  Rapid acquisition of multidimensional solid-state NMR spectra of proteins facilitated by covalently bound paramagnetic tags.

Authors:  Philippe S Nadaud; Jonathan J Helmus; Ishita Sengupta; Christopher P Jaroniec
Journal:  J Am Chem Soc       Date:  2010-07-21       Impact factor: 15.419

3.  Proton Transverse Relaxation as a Sensitive Probe for Structure Determination in Solid Proteins.

Authors:  Petra Rovó; Kristof Grohe; Karin Giller; Stefan Becker; Rasmus Linser
Journal:  Chemphyschem       Date:  2015-10-01       Impact factor: 3.102

Review 4.  The activities of amyloids from a structural perspective.

Authors:  Roland Riek; David S Eisenberg
Journal:  Nature       Date:  2016-11-10       Impact factor: 49.962

5.  Molecular-level examination of Cu2+ binding structure for amyloid fibrils of 40-residue Alzheimer's β by solid-state NMR spectroscopy.

Authors:  Sudhakar Parthasarathy; Fei Long; Yifat Miller; Yiling Xiao; Dan McElheny; Kent Thurber; Buyong Ma; Ruth Nussinov; Yoshitaka Ishii
Journal:  J Am Chem Soc       Date:  2011-02-22       Impact factor: 15.419

6.  Structure of the KcsA potassium channel from Streptomyces lividans: a site-directed spin labeling study of the second transmembrane segment.

Authors:  A Gross; L Columbus; K Hideg; C Altenbach; W L Hubbell
Journal:  Biochemistry       Date:  1999-08-10       Impact factor: 3.162

7.  Evaluation of the influence of intermolecular electron-nucleus couplings and intrinsic metal binding sites on the measurement of 15N longitudinal paramagnetic relaxation enhancements in proteins by solid-state NMR.

Authors:  Philippe S Nadaud; Ishita Sengupta; Jonathan J Helmus; Christopher P Jaroniec
Journal:  J Biomol NMR       Date:  2011-08-09       Impact factor: 2.835

8.  Structural studies of proteins by paramagnetic solid-state NMR spectroscopy.

Authors:  Christopher P Jaroniec
Journal:  J Magn Reson       Date:  2015-04       Impact factor: 2.229

9.  Paramagnetic ions enable tuning of nuclear relaxation rates and provide long-range structural restraints in solid-state NMR of proteins.

Authors:  Philippe S Nadaud; Jonathan J Helmus; Stefanie L Kall; Christopher P Jaroniec
Journal:  J Am Chem Soc       Date:  2009-06-17       Impact factor: 15.419

10.  Vascular variant of prion protein cerebral amyloidosis with tau-positive neurofibrillary tangles: the phenotype of the stop codon 145 mutation in PRNP.

Authors:  B Ghetti; P Piccardo; M G Spillantini; Y Ichimiya; M Porro; F Perini; T Kitamoto; J Tateishi; C Seiler; B Frangione; O Bugiani; G Giaccone; F Prelli; M Goedert; S R Dlouhy; F Tagliavini
Journal:  Proc Natl Acad Sci U S A       Date:  1996-01-23       Impact factor: 11.205
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  8 in total

1.  Peptide bond conformation in peptides and proteins probed by dipolar coupling-chemical shift tensor correlation solid-state NMR.

Authors:  Dwaipayan Mukhopadhyay; Chitrak Gupta; Theint Theint; Christopher P Jaroniec
Journal:  J Magn Reson       Date:  2018-10-30       Impact factor: 2.229

2.  Two decades of progress in structural and dynamic studies of amyloids by solid-state NMR.

Authors:  Christopher P Jaroniec
Journal:  J Magn Reson       Date:  2019-07-09       Impact factor: 2.229

Review 3.  Mechanisms of Strain Diversity of Disease-Associated in-Register Parallel β-Sheet Amyloids and Implications About Prion Strains.

Authors:  Yuzuru Taguchi; Hiroki Otaki; Noriyuki Nishida
Journal:  Viruses       Date:  2019-01-28       Impact factor: 5.048

Review 4.  Structural Consequences of Copper Binding to the Prion Protein.

Authors:  Giulia Salzano; Gabriele Giachin; Giuseppe Legname
Journal:  Cells       Date:  2019-07-25       Impact factor: 6.600

5.  Influence of the Dynamically Disordered N-Terminal Tail Domain on the Amyloid Core Structure of Human Y145Stop Prion Protein Fibrils.

Authors:  Zhe Qi; Krystyna Surewicz; Witold K Surewicz; Christopher P Jaroniec
Journal:  Front Mol Biosci       Date:  2022-02-14

6.  Cryo-EM structures of prion protein filaments from Gerstmann-Sträussler-Scheinker disease.

Authors:  Grace I Hallinan; Kadir A Ozcan; Wen Jiang; Bernardino Ghetti; Ruben Vidal; Md Rejaul Hoq; Laura Cracco; Frank S Vago; Sakshibeedu R Bharath; Daoyi Li; Max Jacobsen; Emma H Doud; Amber L Mosley; Anllely Fernandez; Holly J Garringer
Journal:  Acta Neuropathol       Date:  2022-07-12       Impact factor: 15.887

7.  Conformation-Dependent Influences of Hydrophobic Amino Acids in Two In-Register Parallel β-Sheet Amyloids, an α-Synuclein Amyloid and a Local Structural Model of PrPSc.

Authors:  Hiroki Otaki; Yuzuru Taguchi; Noriyuki Nishida
Journal:  ACS Omega       Date:  2022-08-24

8.  Cryo-EM structure of a human prion fibril with a hydrophobic, protease-resistant core.

Authors:  Calina Glynn; Michael R Sawaya; Peng Ge; Marcus Gallagher-Jones; Connor W Short; Ronquiajah Bowman; Marcin Apostol; Z Hong Zhou; David S Eisenberg; Jose A Rodriguez
Journal:  Nat Struct Mol Biol       Date:  2020-04-13       Impact factor: 15.369
  8 in total

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