Charles S Kamen1, Gwendolyn P Quinn2,3, Matthew Asare1, Charles E Heckler1, Joseph J Guido1, Jeffrey K Giguere4, Kari Gilliland1, Jane Jijun Liu5, Jodi Geer6, Scott E Delacroix7, Gary R Morrow1, Paul B Jacobsen2. 1. Department of Surgery, University of Rochester Medical Center, Rochester, New York. 2. Health Outcomes and Behavior Program, Moffitt Cancer Center, Tampa, Florida. 3. Department of Obstetrics and Gynecology, New York University Medical Center, New York, New York. 4. Greenville Health System Cancer Institute, Seneca, South Carolina. 5. Heartland National Cancer Institute Community Oncology Research Program, Decatur, Illinois. 6. Metro-Minnesota National Cancer Institute Community Oncology Research Program, St. Louis Park, Minnesota. 7. Gulf South Minority Underserved National Cancer Institute Community Oncology Research Program, Louisiana State University Health Sciences Center, New Orleans, Louisiana.
Abstract
BACKGROUND: Supporting patients' decision making about clinical trials may enhance trial participation. To date, few theory-based interventions have been tested to address this issue. The objective of the current study was aimed to evaluate the effect of a multimedia psychoeducation (MP) intervention, relative to a print education (PE) intervention, on patients' decision support needs and attitudes about clinical trials. METHODS:Patients with cancer who were eligible for participation in a National Cancer Institute therapeutic cancer clinical trial were recruited through the nationwide University of Rochester Cancer Center National Cancer Institute Community Oncology Research Program from 2014 to 2016 and were randomized to the MP or PE intervention. Assessments at baseline (before intervention), postintervention, and at a 2-month follow-up visit included patients' decision support needs, attitudes regarding clinical trials, and clinical trial participation. RESULTS: In total, 418 patients with various types of cancer were recruited (ages 26-89 years). Relative to the PE intervention, the MP intervention did not significantly affect decision support needs. However, patients in the MP arm reported significantly more positive attitudes about clinical trials and were more likely to participate in a clinical trial than those in the PE arm (69% vs 62%; P = .01). Furthermore, an improvement in attitudes about clinical trials significantly mediated the effect of the intervention on participation in clinical trials. CONCLUSIONS: The MP intervention was able to improve patient attitudes toward clinical trials compared with the PE intervention, and this improvement led to increased rates of participation in trials. The MP intervention could be disseminated to improve attitudes about clinical trials among patients with cancer.
RCT Entities:
BACKGROUND: Supporting patients' decision making about clinical trials may enhance trial participation. To date, few theory-based interventions have been tested to address this issue. The objective of the current study was aimed to evaluate the effect of a multimedia psychoeducation (MP) intervention, relative to a print education (PE) intervention, on patients' decision support needs and attitudes about clinical trials. METHODS:Patients with cancer who were eligible for participation in a National Cancer Institute therapeutic cancer clinical trial were recruited through the nationwide University of Rochester Cancer Center National Cancer Institute Community Oncology Research Program from 2014 to 2016 and were randomized to the MP or PE intervention. Assessments at baseline (before intervention), postintervention, and at a 2-month follow-up visit included patients' decision support needs, attitudes regarding clinical trials, and clinical trial participation. RESULTS: In total, 418 patients with various types of cancer were recruited (ages 26-89 years). Relative to the PE intervention, the MP intervention did not significantly affect decision support needs. However, patients in the MP arm reported significantly more positive attitudes about clinical trials and were more likely to participate in a clinical trial than those in the PE arm (69% vs 62%; P = .01). Furthermore, an improvement in attitudes about clinical trials significantly mediated the effect of the intervention on participation in clinical trials. CONCLUSIONS: The MP intervention was able to improve patient attitudes toward clinical trials compared with the PE intervention, and this improvement led to increased rates of participation in trials. The MP intervention could be disseminated to improve attitudes about clinical trials among patients with cancer.
Authors: Kuang-Yi Wen; Suzanne M Miller; Annette L Stanton; Linda Fleisher; Marion E Morra; Alexandra Jorge; Michael A Diefenbach; Mary E Ropka; Alfred C Marcus Journal: Patient Educ Couns Date: 2012-07-07
Authors: Kristian D Stensland; Russell B McBride; Asma Latif; Juan Wisnivesky; Ryan Hendricks; Nitin Roper; Paolo Boffetta; Simon J Hall; William K Oh; Matthew D Galsky Journal: J Natl Cancer Inst Date: 2014-09-04 Impact factor: 13.506