Literature DB >> 30275082

High Rate of Ceftobiprole Resistance among Clinical Methicillin-Resistant Staphylococcus aureus Isolates from a Hospital in Central Italy.

Gianluca Morroni1, Andrea Brenciani2, Lucia Brescini1, Simona Fioriti3, Serena Simoni3, Antonella Pocognoli4, Marina Mingoia3, Eleonora Giovanetti5, Francesco Barchiesi1, Andrea Giacometti1, Oscar Cirioni1.   

Abstract

Ceftobiprole is a fifth-generation cephalosporin with activity against methicillin-resistant Staphylococcus aureus (MRSA). One-year surveillance at the Regional Hospital of Ancona (Italy) disclosed a 12% ceftobiprole resistance rate (12/102 isolates; MIC, ≥4 mg/liter). Epidemiological characterization demonstrated that the resistant isolates all belonged to different clones. Penicillin-binding protein (PBP) analysis showed substitutions in all PBPs and a novel insertion in PBP2a. The mecB and mecC genes were not detected. Ceftobiprole susceptibility screening is essential to avoid therapeutic failure and the spread of ceftobiprole-resistant strains.
Copyright © 2018 American Society for Microbiology.

Entities:  

Keywords:  MRSA; ceftobiprole; cephalosporins; mecA gene; penicillin-binding protein

Mesh：

Substances：

Year:  2018        PMID： 30275082      PMCID： PMC6256782          DOI： 10.1128/AAC.01663-18

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  22 in total

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Review 4.  Penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus.

Authors:  Jennifer Fishovitz; Juan A Hermoso; Mayland Chang; Shahriar Mobashery
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Authors:  David J Farrell; Robert K Flamm; Helio S Sader; Ronald N Jones
Journal:  Antimicrob Agents Chemother       Date:  2014-04-28       Impact factor: 5.191

7.  Activity of ceftobiprole against Staphylococcus spec. isolates derived from foreign body associated infections.

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Journal:  Eur J Clin Microbiol Infect Dis       Date:  2018-06-06       Impact factor: 3.267
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