Literature DB >> 25044998

Penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus.

Jennifer Fishovitz1, Juan A Hermoso, Mayland Chang, Shahriar Mobashery.   

Abstract

High-level resistance to β-lactam antibiotics in methicillin-resistant Staphylococcus aureus (MRSA) is due to expression of penicillin-binding protein 2a (PBP2a), a transpeptidase that catalyzes cell-wall crosslinking in the face of the challenge by β-lactam antibiotics. The activity of this protein is regulated by allostery at a site 60 Å distant from the active site, where crosslinking of cell wall takes place. This review discusses the state of knowledge on this important enzyme of cell-wall biosynthesis in MRSA.
© 2014 International Union of Biochemistry and Molecular Biology.

Entities:  

Keywords:  allosteric regulation; conformational change; methicillin-resistant Staphylococcus aureus; resistance mechanism; β-lactam antibiotics

Mesh：

Substances：

Year:  2014        PMID： 25044998      PMCID： PMC4236225          DOI： 10.1002/iub.1289

Source DB:  PubMed          Journal:  IUBMB Life        ISSN： 1521-6543            Impact factor:   3.885


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