| Literature DB >> 17540252 |
Anne Tristan1, Tristan Ferry, Geraldine Durand, Olivier Dauwalder, Michele Bes, Gerard Lina, François Vandenesch, Jerome Etienne.
Abstract
Staphylococcus aureus produces many virulence factors, most of which act in a synergistic and coordinated fashion. Some appear to be specifically associated with certain severe infections and are produced by meticillin-resistant Staphylococcus aureus (MRSA) clones distributed worldwide. Superantigenic exotoxins appear to be major virulence factors in hospital MRSA clones (HA-MRSA), and staphylococcal enterotoxin A (SEA) may be involved in the physiopathology of septic shock. Panton Valentine Leucocidin (PVL) has emerged as a major virulence factor in community-acquired Staphylococcus aureus (CA-MRSA) infections. In particular, the leukotoxic action of PVL is responsible for the high mortality rate associated with necrotizing pneumonia. CA-MRSA can also harbour the toxic shock toxin 1 (TSST-1) and rarely the exfoliative toxin.Entities:
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Year: 2007 PMID： 17540252 DOI： 10.1016/S0195-6701(07)60025-5
Source DB: PubMed Journal: J Hosp Infect ISSN： 0195-6701 Impact factor: 3.926