Literature DB >> 3026648

The c-Ha-ras oncogene and a tumor promoter activate the polyoma virus enhancer.

C Wasylyk, J L Imler, J Perez-Mutul, B Wasylyk.   

Abstract

A c-Ha-ras oncogene, to a lesser extent the c-Ha-ras proto-oncogene, and the tumor promoter 12-O-tetradecanoylphorbol-13-acetate activate the inactive polyoma virus (Py) enhancer in a myeloma cell line and the partially active Py enhancer in NIH 3T3 fibroblasts, but have no effect on the active Py enhancer in LMTK- fibroblasts. In addition, c-Ha-ras can stimulate the inactive Py enhancer in embryonal carcinoma F9 cells. c-Ha-ras activation in embryonal carcinoma cells does not appear to involve reversal of "E1A-like" inhibition of the enhancer. We suggest that modulation of cellular enhancer activity could play a key role in tumorigenesis by oncogenes.

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Year:  1987        PMID： 3026648     DOI： 10.1016/0092-8674(87)90203-0

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  49 in total

1.  The tumor suppressor p53 inhibits Net, an effector of Ras/extracellular signal-regulated kinase signaling.

Authors:  Koji Nakade; Hong Zheng; Gitali Ganguli; Gilles Buchwalter; Christian Gross; Bohdan Wasylyk
Journal:  Mol Cell Biol       Date:  2004-02       Impact factor: 4.272

2.  Metaplastic change in mesenchymal stem cells induced by activated ras oncogene.

Authors:  C Y Tzen; M Filipak; R E Scott
Journal:  Am J Pathol       Date:  1990-11       Impact factor: 4.307

3.  Transfection of insulin-producing cells with a transforming c-Ha-ras oncogene stimulates phospholipase C activity.

Authors:  P O Berggren; A Hallberg; N Welsh; P Arkahammar; T Nilsson; M Welsh
Journal:  Biochem J       Date:  1989-05-01       Impact factor: 3.857

4.  Repression by Jun of the Polyoma-virus enhancer overrides activation in a cell specific manner.

Authors:  J Schneikert; J L Imler; B Wasylyk
Journal:  Nucleic Acids Res       Date:  1991-02-25       Impact factor: 16.971

5.  Transfected human beta-polymerase promoter contains a ras-responsive element.

Authors:  P S Kedar; D R Lowy; S G Widen; S H Wilson
Journal:  Mol Cell Biol       Date:  1990-07       Impact factor: 4.272

6.  Purification of a mouse nuclear factor that binds to both the A and B cores of the polyomavirus enhancer.

Authors:  Y Kamachi; E Ogawa; M Asano; S Ishida; Y Murakami; M Satake; Y Ito; K Shigesada
Journal:  J Virol       Date:  1990-10       Impact factor: 5.103

7.  Loss of responsiveness of an AP1-related factor, PEBP1, to 12-O-tetradecanoylphorbol-13-acetate after transformation of NIH 3T3 cells by the Ha-ras oncogene.

Authors:  M Satake; T Ibaraki; Y Yamaguchi; Y Ito
Journal:  J Virol       Date:  1989-09       Impact factor: 5.103

8.  The transcription factor Net regulates the angiogenic switch.

Authors:  Hong Zheng; Christine Wasylyk; Abdelkader Ayadi; Joseph Abecassis; Jack A Schalken; Hermann Rogatsch; Nicolas Wernert; Sauveur-Michel Maira; Marie-Christine Multon; Bohdan Wasylyk
Journal:  Genes Dev       Date:  2003-09-15       Impact factor: 11.361

9.  Transient expression directed by homologous and heterologous promoter and enhancer sequences in fish cells.

Authors:  H Friedenreich; M Schartl
Journal:  Nucleic Acids Res       Date:  1990-06-11       Impact factor: 16.971

10.  Alpha B crystallin accumulation is a specific response to Ha-ras and v-mos oncogene expression in mouse NIH 3T3 fibroblasts.

Authors:  R Klemenz; E Fröhli; A Aoyama; S Hoffmann; R J Simpson; R L Moritz; R Schäfer
Journal:  Mol Cell Biol       Date:  1991-02       Impact factor: 4.272
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