Literature DB >> 1850124

Repression by Jun of the Polyoma-virus enhancer overrides activation in a cell specific manner.

J Schneikert1, J L Imler, B Wasylyk.   

Abstract

The activities of promoters and enhancers are generated by the combinatorial effects of the factors which interact with them. The Polyoma virus (Py) enhancer contains sequences that are positively regulated by the proto-oncogene Jun. Surprisingly, Jun has an additional and overriding repressing effect on enhancer activity, which is cell specific. Thus overall enhancer activity cannot be simply deduced from the properties of individual elements. We present evidence that repression is indirect.

Entities:  

Mesh：

Substances：

Year:  1991        PMID： 1850124      PMCID： PMC333711          DOI： 10.1093/nar/19.4.783

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  28 in total

Review 1.  Transcriptional repression of eukaryotic promoters.

Authors:  M Levine; J L Manley
Journal:  Cell       Date:  1989-11-03       Impact factor: 41.582

2.  Negative and positive factors determine the activity of the polyoma virus enhancer alpha domain in undifferentiated and differentiated cell types.

Authors:  B Wasylyk; J L Imler; B Chatton; C Schatz; C Wasylyk
Journal:  Proc Natl Acad Sci U S A       Date:  1988-11       Impact factor: 11.205

3.  The c-Ha-ras oncogene and a tumor promoter activate the polyoma virus enhancer.

Authors:  C Wasylyk; J L Imler; J Perez-Mutul; B Wasylyk
Journal:  Cell       Date:  1987-02-13       Impact factor: 41.582

4.  Negative effect of the transcriptional activator GAL4.

Authors:  G Gill; M Ptashne
Journal:  Nature       Date:  1988-08-25       Impact factor: 49.962

5.  v-jun is a transcriptional activator, but not in all cell-lines.

Authors:  J L Imler; E Ugarte; C Wasylyk; B Wasylyk
Journal:  Nucleic Acids Res       Date:  1988-04-11       Impact factor: 16.971

6.  jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun.

Authors:  J Schütte; J Viallet; M Nau; S Segal; J Fedorko; J Minna
Journal:  Cell       Date:  1989-12-22       Impact factor: 41.582

7.  trans-repression of the mouse c-fos promoter: a novel mechanism of Fos-mediated trans-regulation.

Authors:  F C Lucibello; C Lowag; M Neuberg; R Müller
Journal:  Cell       Date:  1989-12-22       Impact factor: 41.582

8.  A Harvey-ras responsive transcription element is also responsive to a tumour-promoter and to serum.

Authors:  J L Imler; C Schatz; C Wasylyk; B Chatton; B Wasylyk
Journal:  Nature       Date:  1988-03-17       Impact factor: 49.962

9.  Repression of c-fos transcription is mediated through p67SRF bound to the SRE.

Authors:  P E Shaw; S Frasch; A Nordheim
Journal:  EMBO J       Date:  1989-09       Impact factor: 11.598

10.  PEA3 is a nuclear target for transcription activation by non-nuclear oncogenes.

Authors:  C Wasylyk; P Flores; A Gutman; B Wasylyk
Journal:  EMBO J       Date:  1989-11       Impact factor: 11.598
View more
  2 in total

Review 1.  Natural biology of polyomavirus middle T antigen.

Authors:  K A Gottlieb; L P Villarreal
Journal:  Microbiol Mol Biol Rev       Date:  2001-06       Impact factor: 11.056

2.  Reversion of a transcriptionally defective MHC class II-negative human B-cell mutant.

Authors:  M N Ombra; C Perfetto; M Autiero; A M Anzisi; R Pasquinelli; A Maffei; G Del Pozzo; J Guardiola
Journal:  Nucleic Acids Res       Date:  1993-02-11       Impact factor: 16.971
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.