| Literature DB >> 30263494 |
Ryota Hosomi1, Ren Otsuka1, Hirofumi Arai2, Seiji Kanda3, Toshimasa Nishiyama3, Munehiro Yoshida1, Kenji Fukunaga1.
Abstract
In an effort to clarify whether the lipid-lowering effect of hemoglobin is due to globin protein or heme, this study investigated the effects of dietary porcine hemoglobin (PH) and porcine globin (PG) on lipids contents of serum, liver, and feces in rats. Five-week-old male Wistar rats were divided into 3 dietary groups of 7 rats each, with one group receiving a control diet and the other groups receiving diets containing 1.25% (w/w) PH or 1.18% (w/w) PG for 4 weeks. The PH diet decreased triacylglycerol content in serum and cholesterol in serum and liver, whereas the PG diet reduced triacylglycerol content in serum and cholesterol in liver. Fecal lipid excretion in the PH group was significantly higher than in the PG group. Therefore, PH affected lipid excretion to feces due to globin protein as well as heme.Entities:
Keywords: cholesterol; globin; heme; lipid excretion; porcine hemoglobin
Year: 2016 PMID： 30263494 PMCID： PMC6049412 DOI： 10.1007/s10068-016-0106-7
Source DB: PubMed Journal: Food Sci Biotechnol ISSN： 1226-7708 Impact factor: 2.391