Literature DB >> 2827007

Phosphorylation of p53 in normal and simian virus 40-transformed NIH 3T3 cells.

D W Meek1, W Eckhart.   

Abstract

We observed six major tryptic phosphopeptides in p53 from simian virus 40-transformed and normal NIH 3T3 cells. Analyses of the phosphopeptides indicated that serines 37, 310 and/or 312, 389 and one or more of serines 7, 9, 12, 18, and 23 were phosphorylated. Phosphorylation of serines 310 and/or 312 was twofold higher in the simian virus 40-transformed cells as compared with that in normal NIH 3T3 cells.

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Year:  1988        PMID： 2827007      PMCID： PMC363151          DOI： 10.1128/mcb.8.1.461-465.1988

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  35 in total

1.  T antigen is bound to a host protein in SV40-transformed cells.

Authors:  D P Lane; L V Crawford
Journal:  Nature       Date:  1979-03-15       Impact factor: 49.962

2.  Characterization of Rous sarcoma virus src gene products synthesized in vitro.

Authors:  K Beemon; T Hunter
Journal:  J Virol       Date:  1978-11       Impact factor: 5.103

3.  Participation of p53 cellular tumour antigen in transformation of normal embryonic cells.

Authors:  D Eliyahu; A Raz; P Gruss; D Givol; M Oren
Journal:  Nature       Date:  1984 Dec 13-19       Impact factor: 49.962

4.  UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells.

Authors:  W Maltzman; L Czyzyk
Journal:  Mol Cell Biol       Date:  1984-09       Impact factor: 4.272

5.  Organization of T antigens in the polyoma virus genome.

Authors:  T Hunter; M A Hutchinson; W Eckhart; T Friedmann; A Esty; P La Porte; P Deininger
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1980

6.  Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells.

Authors:  D I Linzer; A J Levine
Journal:  Cell       Date:  1979-05       Impact factor: 41.582

7.  Simian virus 40-transformed cells express new species of proteins precipitable by anti-simian virus 40 tumor serum.

Authors:  M Kress; E May; R Cassingena; P May
Journal:  J Virol       Date:  1979-08       Impact factor: 5.103

8.  Staphylococcal protease: a proteolytic enzyme specific for glutamoyl bonds.

Authors:  J Houmard; G R Drapeau
Journal:  Proc Natl Acad Sci U S A       Date:  1972-12       Impact factor: 11.205

9.  Reconstitution of p53 expression in a nonproducer Ab-MuLV-transformed cell line by transfection of a functional p53 gene.

Authors:  D Wolf; N Harris; V Rotter
Journal:  Cell       Date:  1984-08       Impact factor: 41.582

10.  Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation.

Authors:  L F Parada; H Land; R A Weinberg; D Wolf; V Rotter
Journal:  Nature       Date:  1984 Dec 13-19       Impact factor: 49.962
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  36 in total

1.  Protein kinase CK2-dependent regulation of p53 function: evidence that the phosphorylation status of the serine 386 (CK2) site of p53 is constitutive and stable.

Authors:  L McKendrick; D Milne; D Meek
Journal:  Mol Cell Biochem       Date:  1999-01       Impact factor: 3.396

2.  p53 functions as a cell cycle control protein in osteosarcomas.

Authors:  L Diller; J Kassel; C E Nelson; M A Gryka; G Litwak; M Gebhardt; B Bressac; M Ozturk; S J Baker; B Vogelstein
Journal:  Mol Cell Biol       Date:  1990-11       Impact factor: 4.272

3.  Mutation of the casein kinase II phosphorylation site abolishes the anti-proliferative activity of p53.

Authors:  D M Milne; R H Palmer; D W Meek
Journal:  Nucleic Acids Res       Date:  1992-11-11       Impact factor: 16.971

Review 4.  Nuclear protein phosphorylation and growth control.

Authors:  D W Meek; A J Street
Journal:  Biochem J       Date:  1992-10-01       Impact factor: 3.857

Review 5.  Posttranslational modification of p53: cooperative integrators of function.

Authors:  David W Meek; Carl W Anderson
Journal:  Cold Spring Harb Perspect Biol       Date:  2009-10-28       Impact factor: 10.005

Review 6.  Protein phosphatases and DNA tumor viruses: transformation through the back door?

Authors:  M C Mumby; G Walter
Journal:  Cell Regul       Date:  1991-08

7.  Simian virus 40 can overcome the antiproliferative effect of wild-type p53 in the absence of stable large T antigen-p53 binding.

Authors:  D Michael-Michalovitz; F Yehiely; E Gottlieb; M Oren
Journal:  J Virol       Date:  1991-08       Impact factor: 5.103

8.  Dephosphorylation of simian virus 40 large-T antigen and p53 protein by protein phosphatase 2A: inhibition by small-t antigen.

Authors:  K H Scheidtmann; M C Mumby; K Rundell; G Walter
Journal:  Mol Cell Biol       Date:  1991-04       Impact factor: 4.272

9.  Human p53 and CDC2Hs genes combine to inhibit the proliferation of Saccharomyces cerevisiae.

Authors:  J M Nigro; R Sikorski; S I Reed; B Vogelstein
Journal:  Mol Cell Biol       Date:  1992-03       Impact factor: 4.272

10.  Human p53 inhibits growth in Schizosaccharomyces pombe.

Authors:  J R Bischoff; D Casso; D Beach
Journal:  Mol Cell Biol       Date:  1992-04       Impact factor: 4.272
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