Literature DB >> 30250909

Complex role of SIRT6 in NF-κB pathway regulation.

Irene Santos-Barriopedro1, Alejandro Vaquero1.   

Abstract

The NF-κB pathway regulates cell physiology under stress conditions. We have recently described a novel NF-κB regulatory mechanism, by which SIRT6 induces cysteine monoubiquitination of the methyltransferase SUV39H1. This causes SUV39H1 dissociation from the gene encoding the NF-κB inhibitor IκBα,  increasing its expression and leading to NF-κB pathway inactivation.

Entities:  

Keywords:  IκBα; NF-κB; SIRT6; SKP2; SUV39H1; Sirtuins, NAD+

Year:  2018        PMID： 30250909      PMCID： PMC6149701          DOI： 10.1080/23723556.2018.1445942

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  Selectivity of the NF-{kappa}B response.

Authors:  Ranjan Sen; Stephen T Smale
Journal:  Cold Spring Harb Perspect Biol       Date:  2009-10-14       Impact factor: 10.005

Review 2.  A drive in SUVs: From development to disease.

Authors:  Vinay Kumar Rao; Ananya Pal; Reshma Taneja
Journal:  Epigenetics       Date:  2017-01-20       Impact factor: 4.528

3.  The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis.

Authors:  Chia-Hsin Chan; Chien-Feng Li; Wei-Lei Yang; Yuan Gao; Szu-Wei Lee; Zizhen Feng; Hsuan-Ying Huang; Kelvin K C Tsai; Leo G Flores; Yiping Shao; John D Hazle; Dihua Yu; Wenyi Wei; Dos Sarbassov; Mien-Chie Hung; Keiichi I Nakayama; Hui-Kuan Lin
Journal:  Cell       Date:  2012-05-25       Impact factor: 41.582

4.  Stabilization of Suv39H1 by SirT1 is part of oxidative stress response and ensures genome protection.

Authors:  Laia Bosch-Presegué; Helena Raurell-Vila; Anna Marazuela-Duque; Noriko Kane-Goldsmith; Adamo Valle; Jordi Oliver; Lourdes Serrano; Alejandro Vaquero
Journal:  Mol Cell       Date:  2011-04-22       Impact factor: 17.970

Review 5.  Chromatin and beyond: the multitasking roles for SIRT6.

Authors:  Sita Kugel; Raul Mostoslavsky
Journal:  Trends Biochem Sci       Date:  2014-01-14       Impact factor: 13.807

6.  SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span.

Authors:  Tiara L A Kawahara; Eriko Michishita; Adam S Adler; Mara Damian; Elisabeth Berber; Meihong Lin; Ron A McCord; Kristine C L Ongaigui; Lisa D Boxer; Howard Y Chang; Katrin F Chua
Journal:  Cell       Date:  2009-01-09       Impact factor: 41.582

7.  Skp2: caught in the Akt.

Authors:  Karin Ecker; Ludger Hengst
Journal:  Nat Cell Biol       Date:  2009-04       Impact factor: 28.824

Review 8.  Non-canonical ubiquitylation: mechanisms and consequences.

Authors:  Gary S McDowell; Anna Philpott
Journal:  Int J Biochem Cell Biol       Date:  2013-05-31       Impact factor: 5.085

9.  SIRT6-dependent cysteine monoubiquitination in the PRE-SET domain of Suv39h1 regulates the NF-κB pathway.

Authors:  Irene Santos-Barriopedro; Laia Bosch-Presegué; Anna Marazuela-Duque; Carolina de la Torre; Carlota Colomer; Berta N Vazquez; Thomas Fuhrmann; Bárbara Martínez-Pastor; Wenfu Lu; Thomas Braun; Eva Bober; Thomas Jenuwein; Lourdes Serrano; Manel Esteller; Zhenbang Chen; Silvia Barceló-Batllori; Raúl Mostoslavsky; Lluis Espinosa; Alejandro Vaquero
Journal:  Nat Commun       Date:  2018-01-09       Impact factor: 14.919

Review 10.  The complexity of NF-κB signaling in inflammation and cancer.

Authors:  Bastian Hoesel; Johannes A Schmid
Journal:  Mol Cancer       Date:  2013-08-02       Impact factor: 27.401
  10 in total
  6 in total

Review 1.  Advances in the role of silence information regulator family in pathological pregnancy.

Authors:  Yingzhou Ge; Xinmei Liu; Hefeng Huang
Journal:  Zhejiang Da Xue Xue Bao Yi Xue Ban       Date:  2021-06-25

2.  Sirt6 Deacetylase: A Potential Key Regulator in the Prevention of Obesity, Diabetes and Neurodegenerative Disease.

Authors:  Swapnil Raj; Liston Augustine Dsouza; Shailendra Pratap Singh; Abhinav Kanwal
Journal:  Front Pharmacol       Date:  2020-12-07       Impact factor: 5.810

3.  SIRT6 inhibition delays peripheral nerve recovery by suppressing migration, phagocytosis and M2-polarization of macrophages.

Authors:  Ying Zou; Jiaqi Zhang; Jiawei Xu; Lanya Fu; Yizhou Xu; Xianghai Wang; Zhenlin Li; Lixin Zhu; Hao Sun; Hui Zheng; Jiasong Guo
Journal:  Cell Biosci       Date:  2021-12-14       Impact factor: 7.133

4.  Alpha Satellite RNA Levels Are Upregulated in the Blood of Patients with Metastatic Castration-Resistant Prostate Cancer.

Authors:  Sven Ljubić; Antonio Sermek; Angela Prgomet Sečan; Marin Prpić; Blanka Jakšić; Jure Murgić; Ana Fröbe; Đurđica Ugarković; Isidoro Feliciello
Journal:  Genes (Basel)       Date:  2022-02-20       Impact factor: 4.096

5.  SIRT6 mediates MRTF-A deacetylation in vascular endothelial cells to antagonize oxLDL-induced ICAM-1 transcription.

Authors:  Shan Huang; Tinghui Shao; Hong Liu; Qianyun Wang; Tianfa Li; Qianwen Zhao
Journal:  Cell Death Discov       Date:  2022-03-04

6.  An Insight into Giant Cell Arteritis Pathogenesis: Evidence for Oxidative Stress and SIRT1 Downregulation.

Authors:  Alessandro Ianni; Poonam Kumari; Shahriar Tarighi; Flavia Rita Argento; Eleonora Fini; Giacomo Emmi; Alessandra Bettiol; Thomas Braun; Domenico Prisco; Claudia Fiorillo; Matteo Becatti
Journal:  Antioxidants (Basel)       Date:  2021-05-31
  6 in total

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