Literature DB >> 19337320

Skp2: caught in the Akt.

Karin Ecker, Ludger Hengst.   

Abstract

To control cell proliferation, signal transduction needs to regulate the cell-cycle machinery. Recent findings show that Akt - a major kinase that coordinates diverse signalling pathways - phosphorylates Skp2, a subunit of the SCF-Skp2 ubiquitin ligase that targets key cell-cycle regulators. Akt1-dependent phosphorylation activates SCF-Skp2 through multiple mechanisms.

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Year:  2009        PMID： 19337320     DOI： 10.1038/ncb0409-377

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  16 in total

1.  Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex.

Authors:  B A Schulman; A C Carrano; P D Jeffrey; Z Bowen; E R Kinnucan; M S Finnin; S J Elledge; J W Harper; M Pagano; N P Pavletich
Journal:  Nature       Date:  2000-11-16       Impact factor: 49.962

2.  Regulation of SCF(SKP2) ubiquitin E3 ligase assembly and p27(KIP1) proteolysis by the PTEN pathway and cyclin D1.

Authors:  Jennifer Harrell Jonason; Nadia Gavrilova; Min Wu; Hui Zhang; Hong Sun
Journal:  Cell Cycle       Date:  2007-04-05       Impact factor: 4.534

3.  Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.

Authors:  Ning Zheng; Brenda A Schulman; Langzhou Song; Julie J Miller; Philip D Jeffrey; Ping Wang; Claire Chu; Deanna M Koepp; Stephen J Elledge; Michele Pagano; Ronald C Conaway; Joan W Conaway; J Wade Harper; Nikola P Pavletich
Journal:  Nature       Date:  2002-04-18       Impact factor: 49.962

Review 4.  The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy.

Authors:  Isabel M Chu; Ludger Hengst; Joyce M Slingerland
Journal:  Nat Rev Cancer       Date:  2008-04       Impact factor: 60.716

5.  Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB.

Authors:  Hui-Kuan Lin; Guocan Wang; Zhenbang Chen; Julie Teruya-Feldstein; Yan Liu; Chia-Hsin Chan; Wei-Lei Yang; Hediye Erdjument-Bromage; Keiichi I Nakayama; Stephen Nimer; Paul Tempst; Pier Paolo Pandolfi
Journal:  Nat Cell Biol       Date:  2009-03-08       Impact factor: 28.824

6.  Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction.

Authors:  Daming Gao; Hiroyuki Inuzuka; Alan Tseng; Rebecca Y Chin; Alex Toker; Wenyi Wei
Journal:  Nat Cell Biol       Date:  2009-03-08       Impact factor: 28.824

7.  A cell cycle regulatory network controlling NF-kappaB subunit activity and function.

Authors:  Benjamin Barré; Neil D Perkins
Journal:  EMBO J       Date:  2007-10-25       Impact factor: 11.598

8.  Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex.

Authors:  Wenyi Wei; Nagi G Ayad; Yong Wan; Guo-Jun Zhang; Marc W Kirschner; William G Kaelin
Journal:  Nature       Date:  2004-03-11       Impact factor: 49.962

Review 9.  Oncogenic properties and prognostic implications of the ubiquitin ligase Skp2 in cancer.

Authors:  Dan D Hershko
Journal:  Cancer       Date:  2008-04-01       Impact factor: 6.860

Review 10.  Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer.

Authors:  David Frescas; Michele Pagano
Journal:  Nat Rev Cancer       Date:  2008-06       Impact factor: 60.716
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  15 in total

1.  Complex role of SIRT6 in NF-κB pathway regulation.

Authors:  Irene Santos-Barriopedro; Alejandro Vaquero
Journal:  Mol Cell Oncol       Date:  2018-05-24

2.  Prodigiosin down-regulates SKP2 to induce p27(KIP1) stabilization and antiproliferation in human lung adenocarcinoma cells.

Authors:  Hsin-Ying Hsieh; Jeng-Jer Shieh; Chun-Jung Chen; Mu-Yun Pan; Shu-Yi Yang; Shin-Chang Lin; Jo-Shu Chang; Alan Yueh-Luen Lee; Chia-Che Chang
Journal:  Br J Pharmacol       Date:  2012-08       Impact factor: 8.739

3.  Expression of p14(ARF), p15(INK4b), p16(INK4a) and skp2 increases during esophageal squamous cell cancer progression.

Authors:  Peng Bai; Xue Xiao; Juan Zou; Lin Cui; Tri M Bui Nguyen; Jinsong Liu; Jianguo Xiao; Bin Chang; Jin Wu; He Wang
Journal:  Exp Ther Med       Date:  2012-03-22       Impact factor: 2.447

4.  14-3-3β Depletion Drives a Senescence Program in Glioblastoma Cells Through the ERK/SKP2/p27 Pathway.

Authors:  Sung Bin Seo; Je-Jung Lee; Hye Hyeon Yun; Chang-Nim Im; Yong-Sam Kim; Jeong-Heon Ko; Jeong-Hwa Lee
Journal:  Mol Neurobiol       Date:  2017-01-23       Impact factor: 5.590

Review 5.  Regulation of Akt signaling activation by ubiquitination.

Authors:  Wei-Lei Yang; Ching-Yuan Wu; Juan Wu; Hui-Kuan Lin
Journal:  Cell Cycle       Date:  2010-02-01       Impact factor: 4.534

6.  RBL2/p130 is a direct AKT target and is required to induce apoptosis upon AKT inhibition in lung cancer and mesothelioma cell lines.

Authors:  Francesca Pentimalli; Iris M Forte; Luca Esposito; Paola Indovina; Carmelina A Iannuzzi; Luigi Alfano; Caterina Costa; Daniela Barone; Gaetano Rocco; Antonio Giordano
Journal:  Oncogene       Date:  2018-04-02       Impact factor: 9.867

7.  Beta-estradiol attenuates hypoxic pulmonary hypertension by stabilizing the expression of p27kip1 in rats.

Authors:  Dun-Quan Xu; Ying Luo; Yi Liu; Jing Wang; Bo Zhang; Min Xu; Yan-Xia Wang; Hai-Ying Dong; Ming-Qing Dong; Peng-Tao Zhao; Wen Niu; Man-Ling Liu; Yu-Qi Gao; Zhi-Chao Li
Journal:  Respir Res       Date:  2010-12-24

8.  ShRNA-targeted centromere protein A inhibits hepatocellular carcinoma growth.

Authors:  Yongmei Li; Zhi Zhu; Shuhui Zhang; Danghui Yu; Hongyu Yu; Lina Liu; Xiaozhe Cao; Li Wang; Hengjun Gao; Minghua Zhu
Journal:  PLoS One       Date:  2011-03-15       Impact factor: 3.240

9.  Statin-induced depletion of geranylgeranyl pyrophosphate inhibits cell proliferation by a novel pathway of Skp2 degradation.

Authors:  Jonathan Vosper; Alessia Masuccio; Michael Kullmann; Christian Ploner; Stephan Geley; Ludger Hengst
Journal:  Oncotarget       Date:  2015-02-20

10.  A novel Hsp90 inhibitor AT13387 induces senescence in EBV-positive nasopharyngeal carcinoma cells and suppresses tumor formation.

Authors:  King Chi Chan; Choi Man Ting; Pui Shan Chan; Ming Chu Lo; Kwok Wai Lo; Jayne E Curry; Tomoko Smyth; Anne Wing Mui Lee; Wai Tong Ng; George Sai Wah Tsao; Ricky Ngok Shun Wong; Maria Li Lung; Nai Ki Mak
Journal:  Mol Cancer       Date:  2013-10-24       Impact factor: 27.401
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