Literature DB >> 30250895

AMPK lifts the PRC2-implemented gene repression.

Tao Han1, Qing Yin1, Lixin Wan1,2.   

Abstract

The crosstalk between cellular energy status and epigenetic modifications remains largely elusive. We recently uncovered that upon energy restriction, AMP-activated protein kinase (AMPK) phosphorylates enhancer of zeste homolog 2 (EZH2), which disrupts the integrity of the polycomb repressive complex 2 (PRC2), thus inhibiting PRC2 oncogenic functions in ovarian and breast cancer cells.

Entities:  

Keywords:  AMPK; EZH2; PRC2; energy restriction

Year:  2018        PMID： 30250895      PMCID： PMC6149850          DOI： 10.1080/23723556.2018.1441632

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  Targeting EZH2 in cancer therapy.

Authors:  Makoto Yamagishi; Kaoru Uchimaru
Journal:  Curr Opin Oncol       Date:  2017-09       Impact factor: 3.645

2.  EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent.

Authors:  Kexin Xu; Zhenhua Jeremy Wu; Anna C Groner; Housheng Hansen He; Changmeng Cai; Rosina T Lis; Xiaoqiu Wu; Edward C Stack; Massimo Loda; Tao Liu; Han Xu; Laura Cato; James E Thornton; Richard I Gregory; Colm Morrissey; Robert L Vessella; Rodolfo Montironi; Cristina Magi-Galluzzi; Philip W Kantoff; Steven P Balk; X Shirley Liu; Myles Brown
Journal:  Science       Date:  2012-12-14       Impact factor: 47.728

Review 3.  Metformin--mode of action and clinical implications for diabetes and cancer.

Authors:  Ida Pernicova; Márta Korbonits
Journal:  Nat Rev Endocrinol       Date:  2014-01-07       Impact factor: 43.330

4.  Phosphorylation of EZH2 by AMPK Suppresses PRC2 Methyltransferase Activity and Oncogenic Function.

Authors:  Lixin Wan; Kexin Xu; Yongkun Wei; Jinfang Zhang; Tao Han; Christopher Fry; Zhao Zhang; Yao Vickie Wang; Liyu Huang; Min Yuan; Weiya Xia; Wei-Chao Chang; Wen-Chien Huang; Chien-Liang Liu; Yuan-Ching Chang; Jinsong Liu; Yun Wu; Victor X Jin; Xiangpeng Dai; Jianfeng Guo; Jia Liu; Shulong Jiang; Jin Li; John M Asara; Myles Brown; Mien-Chie Hung; Wenyi Wei
Journal:  Mol Cell       Date:  2018-01-18       Impact factor: 17.970

5.  Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3.

Authors:  Tai-Lung Cha; Binhua P Zhou; Weiya Xia; Yadi Wu; Cheng-Chieh Yang; Chun-Te Chen; Bo Ping; Arie P Otte; Mien-Chie Hung
Journal:  Science       Date:  2005-10-14       Impact factor: 47.728

Review 6.  Maintaining cell identity: PRC2-mediated regulation of transcription and cancer.

Authors:  Itys Comet; Eva M Riising; Benjamin Leblanc; Kristian Helin
Journal:  Nat Rev Cancer       Date:  2016-09-23       Impact factor: 60.716

Review 7.  AMPK: guardian of metabolism and mitochondrial homeostasis.

Authors:  Sébastien Herzig; Reuben J Shaw
Journal:  Nat Rev Mol Cell Biol       Date:  2017-10-04       Impact factor: 94.444

8.  Phosphoryl-EZH-ion.

Authors:  Giuseppina Caretti; Daniela Palacios; Vittorio Sartorelli; Pier Lorenzo Puri
Journal:  Cell Stem Cell       Date:  2011-03-04       Impact factor: 24.633

Review 9.  The Polycomb complex PRC2 and its mark in life.

Authors:  Raphaël Margueron; Danny Reinberg
Journal:  Nature       Date:  2011-01-20       Impact factor: 49.962

Review 10.  Molecular architecture of polycomb repressive complexes.

Authors:  Emily C Chittock; Sebastian Latwiel; Thomas C R Miller; Christoph W Müller
Journal:  Biochem Soc Trans       Date:  2017-02-08       Impact factor: 5.407
  10 in total
  1 in total

Review 1.  PRC2: an epigenetic multiprotein complex with a key role in the development of rhabdomyosarcoma carcinogenesis.

Authors:  Stefano Zoroddu; Irene Marchesi; Luigi Bagella
Journal:  Clin Epigenetics       Date:  2021-08-09       Impact factor: 6.551
  1 in total

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