Overview of Studies Regarding Mesoporous Silica Nanomaterials and Their Biomedical Application.

Synthesis of mesoporous silica nanomaterials occurred in the late 1980s and early 1990s. Since then, we have seen dramatic increase in the number of publication dealing with this nanomaterial. In particular, there have been a large number of publications regarding biomedical application of mesoporous silica nanoparticles including their use in cancer therapy and diagnosis. Various surface modification strategies have been explored to enhance drug loading and to target them to tumor. In addition, the nanoparticles have been armed with controlled release capability. In this review, we point out some crucial issues regarding the material, which will be discussed in more detail in chapters of this volume.