Literature DB >> 3024169

Sequence homology between acquired immunodeficiency syndrome virus envelope protein and interleukin 2.

W E Reiher, J E Blalock, T K Brunck.   

Abstract

A region of homology has been found between the envelope (env) protein of the acquired immunodeficiency syndrome (AIDS) virus and a portion of interleukin 2 (IL-2) that purportedly binds to the IL-2 receptor. This homology, between two proteins associated with opposing biological functions, suggests possible mechanisms for the immunosuppressive activity of the AIDS virus. Two mechanisms are proposed in which the AIDS virus env protein interferes with IL-2 activity either directly or indirectly. A region of similarity to the purported IL-2 receptor binding site on IL-2 and AIDS virus env is present in the env proteins of other retroviruses associated with immunosuppression. A synthetic peptide vaccine for AIDS is suggested based on the IL-2 receptor binding sequence in AIDS virus env.

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Year:  1986        PMID： 3024169      PMCID： PMC387100          DOI： 10.1073/pnas.83.23.9188

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  34 in total

1.  The immune system in AIDS.

Authors:  J Laurence
Journal:  Sci Am       Date:  1985-12       Impact factor: 2.142

2.  Sequence of the envelope glycoprotein gene of type II human T lymphotropic virus.

Authors:  J Sodroski; R Patarca; D Perkins; D Briggs; T H Lee; M Essex; J Coligan; F Wong-Staal; R C Gallo; W A Haseltine
Journal:  Science       Date:  1984-07-27       Impact factor: 47.728

3.  Nucleotide sequence of Rous sarcoma virus.

Authors:  D E Schwartz; R Tizard; W Gilbert
Journal:  Cell       Date:  1983-03       Impact factor: 41.582

4.  A comprehensive set of sequence analysis programs for the VAX.

Authors:  J Devereux; P Haeberli; O Smithies
Journal:  Nucleic Acids Res       Date:  1984-01-11       Impact factor: 16.971

5.  Nucleotide sequences of the envelope genes of two isolates of feline leukemia virus subgroup B.

Authors:  J H Nunberg; M E Williams; M A Innis
Journal:  J Virol       Date:  1984-02       Impact factor: 5.103

6.  Antibodies reactive with human T-lymphotropic retroviruses (HTLV-III) in the serum of patients with AIDS.

Authors:  M G Sarngadharan; M Popovic; L Bruch; J Schüpbach; R C Gallo
Journal:  Science       Date:  1984-05-04       Impact factor: 47.728

7.  Nucleotide sequence of the simian sarcoma virus genome: demonstration that its acquired cellular sequences encode the transforming gene product p28sis.

Authors:  S G Devare; E P Reddy; J D Law; K C Robbins; S A Aaronson
Journal:  Proc Natl Acad Sci U S A       Date:  1983-02       Impact factor: 11.205

8.  Structure and expression of a cloned cDNA for human interleukin-2.

Authors:  T Taniguchi; H Matsui; T Fujita; C Takaoka; N Kashima; R Yoshimoto; J Hamuro
Journal:  Nature       Date:  1983 Mar 24-30       Impact factor: 49.962

9.  Human adult T-cell leukemia virus: complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA.

Authors:  M Seiki; S Hattori; Y Hirayama; M Yoshida
Journal:  Proc Natl Acad Sci U S A       Date:  1983-06       Impact factor: 11.205

10.  Sequence and expression of the mouse mammary tumour virus env gene.

Authors:  S M Redmond; C Dickson
Journal:  EMBO J       Date:  1983       Impact factor: 11.598
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  16 in total

Review 1.  Molecular mimicry as a mechanism for virus-induced autoimmunity.

Authors:  R S Fujinami; M B Oldstone
Journal:  Immunol Res       Date:  1989       Impact factor: 2.829

Review 2.  B cell responses to HIV and the development of human monoclonal antibodies.

Authors:  J E Boyd; K James
Journal:  Clin Exp Immunol       Date:  1992-05       Impact factor: 4.330

3.  Individuals infected with HIV possess antibodies against IL-2.

Authors:  K L Bost; B H Hahn; M S Saag; G M Shaw; D A Weigent; J E Blalock
Journal:  Immunology       Date:  1988-12       Impact factor: 7.397

4.  Common epitope in human immunodeficiency virus (HIV) I-GP41 and HLA class II elicits immunosuppressive autoantibodies capable of contributing to immune dysfunction in HIV I-infected individuals.

Authors:  H Golding; G M Shearer; K Hillman; P Lucas; J Manischewitz; R A Zajac; M Clerici; R E Gress; R N Boswell; B Golding
Journal:  J Clin Invest       Date:  1989-04       Impact factor: 14.808

5.  Herpes simplex virus-infected cells disarm killer lymphocytes.

Authors:  D L Confer; G M Vercellotti; D Kotasek; J L Goodman; A Ochoa; H S Jacob
Journal:  Proc Natl Acad Sci U S A       Date:  1990-05       Impact factor: 11.205

6.  Synthetic peptides representing sequences within gp41 of HIV as immunogens for murine T- and B-cell responses.

Authors:  L E Brown; D O White; C Agius; B E Kemp; N Yatzakis; P Poumbourios; D A McPhee; D C Jackson
Journal:  Arch Virol       Date:  1995       Impact factor: 2.574

Review 7.  Pathogenesis of human immunodeficiency virus infection.

Authors:  J A Levy
Journal:  Microbiol Rev       Date:  1993-03

8.  Identification of CD4 and major histocompatibility complex functional peptide sites and their homology with oligopeptides from human immunodeficiency virus type 1 glycoprotein gp120: role in AIDS pathogenesis.

Authors:  J F Zagury; J Bernard; A Achour; A Astgen; A Lachgar; L Fall; C Carelli; W Issing; J P Mbika; O Picard
Journal:  Proc Natl Acad Sci U S A       Date:  1993-08-15       Impact factor: 11.205

9.  A monocyte chemotaxis inhibiting factor in serum of HIV infected men shares epitopes with the HIV transmembrane protein gp41.

Authors:  M Tas; H A Drexhage; J Goudsmit
Journal:  Clin Exp Immunol       Date:  1988-01       Impact factor: 4.330

10.  Presence of antibodies to a putatively immunosuppressive part of human immunodeficiency virus (HIV) envelope glycoprotein gp41 is strongly associated with health among HIV-positive subjects.

Authors:  P J Klasse; R Pipkorn; J Blomberg
Journal:  Proc Natl Acad Sci U S A       Date:  1988-07       Impact factor: 11.205
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