Literature DB >> 6403867

Structure and expression of a cloned cDNA for human interleukin-2.

T Taniguchi, H Matsui, T Fujita, C Takaoka, N Kashima, R Yoshimoto, J Hamuro.   

Abstract

A cDNA coding for human interleukin-2 (IL-2) has been cloned from a cDNA library prepared from partially purified IL-2 mRNA. The DNA sequence codes for a polypeptide which consists of 153 amino acids including a putative signal sequence. A biologically active polypeptide, characteristic of human IL-2, was produced when the cDNA was fused to a simian virus 40 promoter sequence and used to transfect cultured monkey COS cells.

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Year:  1983        PMID： 6403867     DOI： 10.1038/302305a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  248 in total

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