Irina Leonardi1,2, Xin Li1,2, Iliyan D Iliev1,2,3,4. 1. Gastroenterology and Hepatology Division, Joan and Sanford I. Weill Department of Medicine. 2. Joan and Sanford I. Weill Department of Medicine, The Jill Roberts Institute for Research in Inflammatory Bowel Disease. 3. Department of Microbiology and Immunology, Joan and Sanford I. Weill Department of Medicine. 4. Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, Cornell University, New York, New York, USA.
Abstract
PURPOSE OF REVIEW: In this review, we discuss recent advances into delineating the dual role of intestinal phagocytes in health and during intestinal disease. We further discuss the key role of gut-resident macrophages in recognition of bacterial and fungal microbiota in the gut. RECENT FINDINGS: Inflammatory bowel disease (IBD) commonly manifests with pathologic changes in the composition of gut bacterial and fungal microbiota. Intestinal macrophages are key regulators of the balance between tolerogenic immunity and inflammation. Recent studies have highlighted the role of resident intestinal macrophages in the control of commensal fungi and bacteria in the steady state and during dysbiosis. The dual role of these cells in maintaining intestinal homeostasis and responding to microbiota dysbiosis during inflammation is being increasingly studied. SUMMARY: It is becoming increasingly clear that an aberrant proinflammatory response to microbiota by infiltrating monocytes plays a role in the development of intestinal inflammation. Intestinal mononuclear phagocytes with characteristics of macrophages play an important role in limiting fungal and bacterial overgrowth under these conditions, but can be influenced by the inflammatory environment to further propel inflammation. Better understanding of the interaction of intestinal macrophages with host microbiota including commensal fungi and bacteria, provides an opportunity for the development of more targeted therapies for IBD.
PURPOSE OF REVIEW: In this review, we discuss recent advances into delineating the dual role of intestinal phagocytes in health and during intestinal disease. We further discuss the key role of gut-resident macrophages in recognition of bacterial and fungal microbiota in the gut. RECENT FINDINGS:Inflammatory bowel disease (IBD) commonly manifests with pathologic changes in the composition of gut bacterial and fungal microbiota. Intestinal macrophages are key regulators of the balance between tolerogenic immunity and inflammation. Recent studies have highlighted the role of resident intestinal macrophages in the control of commensal fungi and bacteria in the steady state and during dysbiosis. The dual role of these cells in maintaining intestinal homeostasis and responding to microbiota dysbiosis during inflammation is being increasingly studied. SUMMARY: It is becoming increasingly clear that an aberrant proinflammatory response to microbiota by infiltrating monocytes plays a role in the development of intestinal inflammation. Intestinal mononuclear phagocytes with characteristics of macrophages play an important role in limiting fungal and bacterial overgrowth under these conditions, but can be influenced by the inflammatory environment to further propel inflammation. Better understanding of the interaction of intestinal macrophages with host microbiota including commensal fungi and bacteria, provides an opportunity for the development of more targeted therapies for IBD.
Authors: Iliyan D Iliev; Vincent A Funari; Kent D Taylor; Quoclinh Nguyen; Christopher N Reyes; Samuel P Strom; Jordan Brown; Courtney A Becker; Phillip R Fleshner; Marla Dubinsky; Jerome I Rotter; Hanlin L Wang; Dermot P B McGovern; Gordon D Brown; David M Underhill Journal: Science Date: 2012-06-06 Impact factor: 47.728
Authors: J Magarian Blander; Randy S Longman; Iliyan D Iliev; Gregory F Sonnenberg; David Artis Journal: Nat Immunol Date: 2017-07-19 Impact factor: 25.606
Authors: Xiaonan Han; Kanji Uchida; Ingrid Jurickova; Diana Koch; Tara Willson; Charles Samson; Erin Bonkowski; Anna Trauernicht; Mi-Ok Kim; Gitit Tomer; Marla Dubinsky; Scott Plevy; Subra Kugathsan; Bruce C Trapnell; Lee A Denson Journal: Gastroenterology Date: 2008-12-24 Impact factor: 22.682
Authors: Ling-Shiang Chuang; Nicole Villaverde; Ken Y Hui; Arthur Mortha; Adeeb Rahman; Adam P Levine; Talin Haritunians; Sok Meng Evelyn Ng; Wei Zhang; Nai-Yun Hsu; Jody-Ann Facey; Tramy Luong; Heriberto Fernandez-Hernandez; Dalin Li; Manuel Rivas; Elena R Schiff; Alexander Gusev; L Phillip Schumm; Beatrice M Bowen; Yashoda Sharma; Kaida Ning; Romain Remark; Sacha Gnjatic; Peter Legnani; James George; Bruce E Sands; Joanne M Stempak; Lisa W Datta; Seth Lipka; Seymour Katz; Adam S Cheifetz; Nir Barzilai; Nikolas Pontikos; Clara Abraham; Marla J Dubinsky; Stephan Targan; Kent Taylor; Jerome I Rotter; Ellen J Scherl; Robert J Desnick; Maria T Abreu; Hongyu Zhao; Gil Atzmon; Itsik Pe'er; Subra Kugathasan; Hakon Hakonarson; Jacob L McCauley; Todd Lencz; Ariel Darvasi; Vincent Plagnol; Mark S Silverberg; Aleixo M Muise; Steven R Brant; Mark J Daly; Anthony W Segal; Richard H Duerr; Miriam Merad; Dermot P B McGovern; Inga Peter; Judy H Cho Journal: Gastroenterology Date: 2016-07-01 Impact factor: 22.682
Authors: M K Magnusson; S F Brynjólfsson; A Dige; H Uronen-Hansson; L G Börjesson; J L Bengtsson; S Gudjonsson; L Öhman; J Agnholt; H Sjövall; W W Agace; M J Wick Journal: Mucosal Immunol Date: 2015-06-17 Impact factor: 7.313
Authors: Isabelle A M van Thiel; Shafaque Rahman; Theodorus B M Hakvoort; Mark Davids; Caroline Verseijden; Patricia H P van Hamersveld; Mèlanie V Bénard; Maarten H Lodders; Teun Boekhout; René M van den Wijngaard; Sigrid E M Heinsbroek; Cyriel Y Ponsioen; Wouter J de Jonge Journal: Microorganisms Date: 2022-03-29
Authors: Antonia Last; Michelle Maurer; Alexander S Mosig; Mark S Gresnigt; Bernhard Hube Journal: FEMS Microbiol Rev Date: 2021-09-08 Impact factor: 16.408