| Literature DB >> 29326275 |
Irina Leonardi1,2, Xin Li1,2, Alexa Semon1,2, Dalin Li3, Itai Doron1,2, Gregory Putzel2, Agnieszka Bar1,2, Daniel Prieto4, Maria Rescigno5, Dermot P B McGovern3, Jesus Pla4, Iliyan D Iliev1,2,6.
Abstract
Intestinal fungi are an important component of the microbiota, and recent studies have unveiled their potential in modulating host immune homeostasis and inflammatory disease. Nonetheless, the mechanisms governing immunity to gut fungal communities (mycobiota) remain unknown. We identified CX3CR1+ mononuclear phagocytes (MNPs) as being essential for the initiation of innate and adaptive immune responses to intestinal fungi. CX3CR1+ MNPs express antifungal receptors and activate antifungal responses in a Syk-dependent manner. Genetic ablation of CX3CR1+ MNPs in mice led to changes in gut fungal communities and to severe colitis that was rescued by antifungal treatment. In Crohn's disease patients, a missense mutation in the gene encoding CX3CR1 was identified and found to be associated with impaired antifungal responses. These results unravel a role of CX3CR1+ MNPs in mediating interactions between intestinal mycobiota and host immunity at steady state and during inflammatory disease.Entities:
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Year: 2018 PMID： 29326275 PMCID： PMC5805464 DOI： 10.1126/science.aao1503
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728