Literature DB >> 30237955

Genetic variations of the Hemagglutinin gene of Pandemic Influenza A (H1N1) viruses in Assam, India during 2016.

Kimmi Sarmah1, Biswajyoti Borkakoty1, Kishore Sarma1, Rahul Hazarika1, Palash Kumar Das1, Aniruddha Jakharia1, Mandakini Das1, Dipankar Biswas1.   

Abstract

Since its emergence in 2009, Influenza A/H1N1pdm09 virus has evolved continuously. Marked genetic variations have occurred in the HA1 domain of the hemagglutinin gene causing the emergence of new variants. The present study genetically characterized the hemagglutinin (HA) gene of Influenza A/H1N1pdm09 strains from Assam circulating in 2016 that caused a mild outbreak without any reported mortality. Sequence analysis of the HA gene of 20 positive Assam/H1N1pdm09 strains revealed 3 mutations (K180Q, S202T, S220T) at the antigenic sites along with several other reported mutations which are in close proximity to the antigenic sites and therefore might affect the viral antigenicity. Phylogenetically, the Assam/H1N1pdm09 strains clustered into genogroup 6B. These genetic variations highlight the importance of continuous surveillance and characterization of Influenza A/H1N1pdm09 virus activity to track the genetic makeup and diversification that may affect the behavior of the virus.

Entities:  

Keywords:  Assam; Genetic variation; Hemagglutinin; Influenza A virus; Swine flu H1N1

Year:  2018        PMID： 30237955      PMCID： PMC6138005          DOI： 10.1007/s13205-018-1427-4

Source DB:  PubMed          Journal:  3 Biotech        ISSN： 2190-5738            Impact factor:   2.406


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