Giorgio Cacciola1, Federico De Meo2, Pietro Cavaliere2. 1. University of Messina, Department of Biomedical and Dental Science and Biomorphological Imaging, Via Consolare Valeria 1, Messina, Italy. 2. Istituto Ortopedico del Mezzogiorno d'Italia "Franco Scalabrino", Via Consolare Pompea 360, Messina, Italia, Italy.
Abstract
OBJECTIVE: Periprosthetic Joint Infection (PjI) is considered one of the most difficult complication to manage after total knee or hip arthroplasty, with a mean incidence of 1%. Antibiotic loaded bone cement is used as prophylaxis during primary arthroplasty and as local therapy during two-stage revision. The aim of this study is to evaluate the mechanical and elution properties of G3 Low Viscosity Bone Cement (G-21 San Possidonio, Modena, Italy) loaded with different doses of up to three antibiotics (12 specimens). METHODS: Compressive Strength, Bending Strength and Bending Modulus were evaluated. Cumulative Vancomycin elution by adding different doses of antibiotics was evaluated. RESULTS: The mean Compressive Strength was 81.55 MPa, the mean Bending Strength was 2161.7 MPa, and the mean Bending Modulus was 36.6 MPa. The highest cumulative Vancomycin elution was observed in specimen 12 (1906.9 mg at 2 weeks). This is the first study, at our knowledge, that analysed how cement mechanical properties, and antibiotic elution kinetics, are modified by adding up to three antibiotic. CONCLUSION: The results obtained in this pilot study using G3 Low-Viscosity Bone Cement, demonstrated that mechanical properties not decrease significantly by adding large doses of antibiotics, while the Vancomycin elution increase until swelled to twice.
OBJECTIVE: Periprosthetic Joint Infection (PjI) is considered one of the most difficult complication to manage after total knee or hip arthroplasty, with a mean incidence of 1%. Antibiotic loaded bone cement is used as prophylaxis during primary arthroplasty and as local therapy during two-stage revision. The aim of this study is to evaluate the mechanical and elution properties of G3 Low Viscosity Bone Cement (G-21 San Possidonio, Modena, Italy) loaded with different doses of up to three antibiotics (12 specimens). METHODS: Compressive Strength, Bending Strength and Bending Modulus were evaluated. Cumulative Vancomycin elution by adding different doses of antibiotics was evaluated. RESULTS: The mean Compressive Strength was 81.55 MPa, the mean Bending Strength was 2161.7 MPa, and the mean Bending Modulus was 36.6 MPa. The highest cumulative Vancomycin elution was observed in specimen 12 (1906.9 mg at 2 weeks). This is the first study, at our knowledge, that analysed how cement mechanical properties, and antibiotic elution kinetics, are modified by adding up to three antibiotic. CONCLUSION: The results obtained in this pilot study using G3 Low-Viscosity Bone Cement, demonstrated that mechanical properties not decrease significantly by adding large doses of antibiotics, while the Vancomycin elution increase until swelled to twice.
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Authors: Giorgio Cacciola; Fabio Mancino; Federico De Meo; Vincenzo Di Matteo; Peter K Sculco; Pietro Cavaliere; Giulio Maccauro; Ivan De Martino Journal: J Orthop Date: 2021-02-22
Authors: Giorgio Cacciola; Fabio Mancino; Federico De Meo; Antongiulio Bruschetta; Ivan De Martino; Pietro Cavaliere Journal: Geriatr Orthop Surg Rehabil Date: 2021-08-27
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