Literature DB >> 3023699

A new common integration region (int-3) for mouse mammary tumor virus on mouse chromosome 17.

D Gallahan, C Kozak, R Callahan.   

Abstract

Mus musculus subsp. musculus (Czech II) mammary tumor DNA frequently contains an integrated proviral genome of the mouse mammary tumor virus (MMTV) within a specific 0.5-kilobase-pair region of the cellular genome (designated int-3). Viral integration at this site results in activation of expression of an adjacent cellular gene. We mapped int-3 to mouse chromosome 17 by analysis of PstI-restricted cellular DNAs from mouse-hamster somatic cell hybrids. Restriction analysis of cellular DNA from (C3H/OuJ X Czech II) X Czech II backcross mice established the gene order T-H-2-int-3. These results demonstrated that the int-3 locus is distinct from two other common integration regions for mouse mammary tumor virus (designated int-1 and int-2) in mammary tumor DNA and suggest that several cellular genes may be at risk for virally induced activation during mammary tumor development.

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Year:  1987        PMID： 3023699      PMCID： PMC255246     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  19 in total

1.  A new genetic locus, Bevi, on human chromosome 6 which controls the replication of baboon type C virus in human cells.

Authors:  R S Lemons; S J O'Brien; C J Sherr
Journal:  Cell       Date:  1977-09       Impact factor: 41.582

Review 2.  Genetic organization of the mouse t complex.

Authors:  L M Silver
Journal:  Cell       Date:  1981-12       Impact factor: 41.582

3.  Mammary tumorigenesis in feral mice: identification of a new int locus in mouse mammary tumor virus (Czech II)-induced mammary tumors.

Authors:  D Gallahan; R Callahan
Journal:  J Virol       Date:  1987-01       Impact factor: 5.103

4.  Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome.

Authors:  R Nusse; H E Varmus
Journal:  Cell       Date:  1982-11       Impact factor: 41.582

5.  Molecular clones of the mouse t complex derived from microdissected metaphase chromosomes.

Authors:  D Röhme; H Fox; B Herrmann; A M Frischauf; J E Edström; P Mains; L M Silver; H Lehrach
Journal:  Cell       Date:  1984-03       Impact factor: 41.582

6.  Novel class of mouse mammary tumor virus-related DNA sequences found in all species of Mus, including mice lacking the virus proviral genome.

Authors:  R Callahan; W Drohan; D Gallahan; L D'Hoostelaere; M Potter
Journal:  Proc Natl Acad Sci U S A       Date:  1982-07       Impact factor: 11.205

7.  Genetic mapping of a mouse chromosomal locus required for mink cell focus-forming virus replication.

Authors:  C A Kozak
Journal:  J Virol       Date:  1983-10       Impact factor: 5.103

8.  Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15.

Authors:  R Nusse; A van Ooyen; D Cox; Y K Fung; H Varmus
Journal:  Nature       Date:  1984 Jan 12-18       Impact factor: 49.962

9.  Targeted integration of baboon endogenous virus in the BEVI locus on human chromosome 6.

Authors:  J C Cohen; M Murphey-Corb
Journal:  Nature       Date:  1983-01-13       Impact factor: 49.962

10.  Tumorigenesis by mouse mammary tumor virus: evidence for a common region for provirus integration in mammary tumors.

Authors:  G Peters; S Brookes; R Smith; C Dickson
Journal:  Cell       Date:  1983-06       Impact factor: 41.582
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  42 in total

Review 1.  A role for fibroblast growth factor signaling in the lobuloalveolar development of the mammary gland.

Authors:  D Jackson; J Bresnick; C Dickson
Journal:  J Mammary Gland Biol Neoplasia       Date:  1997-10       Impact factor: 2.673

Review 2.  Notch signaling in mammary development and oncogenesis.

Authors:  Robert Callahan; Sean E Egan
Journal:  J Mammary Gland Biol Neoplasia       Date:  2004-04       Impact factor: 2.673

Review 3.  Notch and the awesome power of genetics.

Authors:  Iva Greenwald
Journal:  Genetics       Date:  2012-07       Impact factor: 4.562

Review 4.  Pro-oncogenic and anti-oncogenic pathways: opportunities and challenges of cancer therapy.

Authors:  Jiao Zhang; Yan-Hua Chen; Qun Lu
Journal:  Future Oncol       Date:  2010-04       Impact factor: 3.404

5.  Glucocorticoid and growth factor synergism requirement for Notch4 chromatin domain activation.

Authors:  Jing Wu; Emery H Bresnick
Journal:  Mol Cell Biol       Date:  2007-01-12       Impact factor: 4.272

Review 6.  Notch as a tumour suppressor.

Authors:  Craig S Nowell; Freddy Radtke
Journal:  Nat Rev Cancer       Date:  2017-02-03       Impact factor: 60.716

7.  Expression of the int-1 and int-2 loci in endogenous mouse mammary tumor virus-induced mammary tumorigenesis in the C3Hf mouse.

Authors:  P R Etkind
Journal:  J Virol       Date:  1989-11       Impact factor: 5.103

Review 8.  The Notch signaling pathway as a mediator of tumor survival.

Authors:  Kathleen M Capaccione; Sharon R Pine
Journal:  Carcinogenesis       Date:  2013-04-12       Impact factor: 4.944

9.  Identification of a common viral integration region in Cas-Br-E murine leukemia virus-induced non-T-, non-B-cell lymphomas.

Authors:  D Bergeron; L Poliquin; C A Kozak; E Rassart
Journal:  J Virol       Date:  1991-01       Impact factor: 5.103

Review 10.  Genetic alterations in primary breast cancer.

Authors:  R Callahan
Journal:  Breast Cancer Res Treat       Date:  1989-07       Impact factor: 4.872
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