Literature DB >> 2552179

Expression of the int-1 and int-2 loci in endogenous mouse mammary tumor virus-induced mammary tumorigenesis in the C3Hf mouse.

P R Etkind1.   

Abstract

The int-1 locus appears to be involved in over 80% of C3H exogenous mouse mammary tumor virus (MMTV)-induced mouse mammary tumors, and the int-2 locus appears to be involved in approximately 10% of these tumors. Analysis of 46 C3Hf mammary tumors resulting from endogenous, rather than exogenous, MMTV infection revealed that only 41% expressed int-1 RNA, while 2% expressed int-2 RNA. Our results suggest that in addition to the int-1 and int-2 loci, other loci may be involved in endogenous-MMTV-induced mammary tumors of the C3Hf mouse.

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Year:  1989        PMID： 2552179      PMCID： PMC251149          DOI： 10.1128/JVI.63.11.4972-4975.1989

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  32 in total

1.  Analysis of endonuclease R-EcoRI fragments of DNA from lambdoid bacteriophages and other viruses by agarose-gel electrophoresis.

Authors:  R B Helling; H M Goodman; H W Boyer
Journal:  J Virol       Date:  1974-11       Impact factor: 5.103

2.  A common mouse mammary tumor virus integration site in chemically induced precancerous mammary hyperplasias.

Authors:  D A Gray; C M McGrath; R F Jones; V L Morris
Journal:  Virology       Date:  1986-01-30       Impact factor: 3.616

3.  Tumorigenesis by mouse mammary tumor virus: proviral activation of a cellular gene in the common integration region int-2.

Authors:  C Dickson; R Smith; S Brookes; G Peters
Journal:  Cell       Date:  1984-06       Impact factor: 41.582

4.  Activation of cellular gene by mouse mammary tumour virus may occur early in mammary tumour development.

Authors:  G Peters; A E Lee; C Dickson
Journal:  Nature       Date:  1984 May 17-23       Impact factor: 49.962

5.  Transcription of mouse mammary tumor virus: identification of a candidate mRNA for the long terminal repeat gene product.

Authors:  D A Wheeler; J S Butel; D Medina; R D Cardiff; G L Hager
Journal:  J Virol       Date:  1983-04       Impact factor: 5.103

6.  Structure and nucleotide sequence of the putative mammary oncogene int-1; proviral insertions leave the protein-encoding domain intact.

Authors:  A van Ooyen; R Nusse
Journal:  Cell       Date:  1984-11       Impact factor: 41.582

7.  Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15.

Authors:  R Nusse; A van Ooyen; D Cox; Y K Fung; H Varmus
Journal:  Nature       Date:  1984 Jan 12-18       Impact factor: 49.962

8.  Tumorigenesis by mouse mammary tumor virus: evidence for a common region for provirus integration in mammary tumors.

Authors:  G Peters; S Brookes; R Smith; C Dickson
Journal:  Cell       Date:  1983-06       Impact factor: 41.582

9.  Proteins encoded by the long terminal repeat region of mouse mammary tumor virus: identification by hybrid-selected translation.

Authors:  J Racevskis; O Prakash
Journal:  J Virol       Date:  1984-09       Impact factor: 5.103

10.  A new site of integration for mouse mammary tumor virus proviral DNA common to BALB/cf(C3H) mammary and kidney adenocarcinomas.

Authors:  M Garcia; R Wellinger; A Vessaz; H Diggelmann
Journal:  EMBO J       Date:  1986-01       Impact factor: 11.598
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  1 in total

1.  Host genetic background effect on the frequency of mouse mammary tumor virus-induced rearrangements of the int-1 and int-2 loci in mouse mammary tumors.

Authors:  A Marchetti; J Robbins; G Campbell; F Buttitta; F Squartini; M Bistocchi; R Callahan
Journal:  J Virol       Date:  1991-08       Impact factor: 5.103
  1 in total

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