Literature DB >> 6092962

Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines.

G D Yancopoulos, S V Desiderio, M Paskind, J F Kearney, D Baltimore, F W Alt.   

Abstract

The most JH-proximal VH gene segments are used highly preferentially to form VHDJH rearrangements in pre-B-cell lines. This result demonstrates that the rate at which immunoglobulin VH gene segments recombine is influenced by their chromosomal organization, and that the initial repertoire of VH genes expressed in pre-B cells is strikingly different from that seen in mature populations.

Mesh：

Substances：

Year:  1984        PMID： 6092962     DOI： 10.1038/311727a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  196 in total

1.  Third complementarity-determining region of mutated VH immunoglobulin genes contains shorter V, D, J, P, and N components than non-mutated genes.

Authors:  K Rosner; D B Winter; R E Tarone; G L Skovgaard; V A Bohr; P J Gearhart
Journal:  Immunology       Date:  2001-06       Impact factor: 7.397

Review 2.  Regulation and chance in the ontogeny of B and T cell antigen receptor repertoires.

Authors:  Michael Zemlin; Robert L Schelonka; Karl Bauer; Harry W Schroeder
Journal:  Immunol Res       Date:  2002       Impact factor: 2.829

3.  The genomic arrangement of T cell receptor variable genes is a determinant of the developmental rearrangement pattern.

Authors:  Na Xiong; Jeanne E Baker; Chulho Kang; David H Raulet
Journal:  Proc Natl Acad Sci U S A       Date:  2003-12-22       Impact factor: 11.205

4.  Changes in histone acetylation are associated with differences in accessibility of V(H) gene segments to V-DJ recombination during B-cell ontogeny and development.

Authors:  Kristen Johnson; Cristina Angelin-Duclos; Sinae Park; Kathryn L Calame
Journal:  Mol Cell Biol       Date:  2003-04       Impact factor: 4.272

5.  Tumorigenesis mediated by an antigen receptor.

Authors:  H M Jäck; G Beck-Engeser; G Lee; D Wofsy; M Wabl
Journal:  Proc Natl Acad Sci U S A       Date:  1992-09-15       Impact factor: 11.205

Review 6.  Pairing of VK and VK gene families in self-reactive antibodies.

Authors:  C A Bona; Y Saitoh; G Kelsoe
Journal:  J Clin Immunol       Date:  1990-09       Impact factor: 8.317

7.  Preferential utilization of conserved immunoglobulin heavy chain variable gene segments during human fetal life.

Authors:  H W Schroeder; J Y Wang
Journal:  Proc Natl Acad Sci U S A       Date:  1990-08       Impact factor: 11.205

8.  Recombination and transcription of the endogenous Ig heavy chain locus is effected by the Ig heavy chain intronic enhancer core region in the absence of the matrix attachment regions.

Authors:  E Sakai; A Bottaro; L Davidson; B P Sleckman; F W Alt
Journal:  Proc Natl Acad Sci U S A       Date:  1999-02-16       Impact factor: 11.205

Review 9.  Regulation of the antibody repertoire through control of HCDR3 diversity.

Authors:  H W Schroeder; G C Ippolito; S Shiokawa
Journal:  Vaccine       Date:  1998 Aug-Sep       Impact factor: 3.641

10.  Evolution of immunoglobulin heavy chain variable region genes: a VH family can last for 150-200 million years or longer.

Authors:  E Andersson; T Matsunaga
Journal:  Immunogenetics       Date:  1995       Impact factor: 2.846
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.