Zijing Dong1, Fuyixue Wang2,3, Timothy G Reese2, Mary Katherine Manhard2, Berkin Bilgic2, Lawrence L Wald2,3, Hua Guo1, Kawin Setsompop2,3. 1. Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China. 2. A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts. 3. Harvard-MIT Health Sciences and Technology, MIT, Cambridge, Massachusetts.
Abstract
PURPOSE: To develop a method for fast distortion- and blurring-free imaging. THEORY: EPI with point-spread-function (PSF) mapping can achieve distortion- and blurring-free imaging at a cost of long acquisition time. In this study, an acquisition/reconstruction technique, termed "tilted-CAIPI," is proposed to achieve >20× acceleration for PSF-EPI. The proposed method systematically optimized the k-space sampling trajectory with B0 -inhomogeneity-informed reconstruction, to exploit the inherent signal correlation in PSF-EPI and take full advantage of coil sensitivity. Susceptibility-induced phase accumulation is regarded as an additional encoding that is estimated by calibration data and integrated into reconstruction. Self-navigated phase correction was developed to correct shot-to-shot phase variation in diffusion imaging. METHODS: Tilted-CAIPI was implemented at 3T, with incorporation of partial Fourier and simultaneous multislice to achieve further accelerations. T2 -weighted, T2 * -weighted, and diffusion-weighted imaging experiments were conducted to evaluate the proposed method. RESULTS: The ability of tilted-CAIPI to provide highly accelerated imaging without distortion and blurring was demonstrated through in vivo brain experiments, where only 8 shots per simultaneous slice group were required to provide high-quality, high-SNR imaging at 0.8-1 mm resolution. CONCLUSION: Tilted-CAIPI achieved fast distortion- and blurring-free imaging with high SNR. Whole-brain T2 -weighted, T2 * -weighted, and diffusion imaging can be obtained in just 15-60 s.
PURPOSE: To develop a method for fast distortion- and blurring-free imaging. THEORY: EPI with point-spread-function (PSF) mapping can achieve distortion- and blurring-free imaging at a cost of long acquisition time. In this study, an acquisition/reconstruction technique, termed "tilted-CAIPI," is proposed to achieve >20× acceleration for PSF-EPI. The proposed method systematically optimized the k-space sampling trajectory with B0 -inhomogeneity-informed reconstruction, to exploit the inherent signal correlation in PSF-EPI and take full advantage of coil sensitivity. Susceptibility-induced phase accumulation is regarded as an additional encoding that is estimated by calibration data and integrated into reconstruction. Self-navigated phase correction was developed to correct shot-to-shot phase variation in diffusion imaging. METHODS: Tilted-CAIPI was implemented at 3T, with incorporation of partial Fourier and simultaneous multislice to achieve further accelerations. T2 -weighted, T2 * -weighted, and diffusion-weighted imaging experiments were conducted to evaluate the proposed method. RESULTS: The ability of tilted-CAIPI to provide highly accelerated imaging without distortion and blurring was demonstrated through in vivo brain experiments, where only 8 shots per simultaneous slice group were required to provide high-quality, high-SNR imaging at 0.8-1 mm resolution. CONCLUSION: Tilted-CAIPI achieved fast distortion- and blurring-free imaging with high SNR. Whole-brain T2 -weighted, T2 * -weighted, and diffusion imaging can be obtained in just 15-60 s.
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