Justin B Echouffo-Tcheugui1, Andre P Kengne2, Mohammed K Ali3,4. 1. Department of Medicine, Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital/Harvard Medical School, 221 Longwood Avenue, Boston, MA, 02115, USA. echouffotcheugui@gmail.com. 2. Non-Communicable Diseases Research Unit, South African Medical Research Council, Cape Town, South Africa. 3. Department of Family and Preventive Medicine, Emory University, Atlanta, GA, USA. 4. Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Abstract
PURPOSE OF REVIEW: Using a global perspective, this review collates evidence on the heterogeneity of prediabetes definitions and diagnostic methods, their clinical and public health implications, and discusses possible options for improvement. RECENT FINDINGS: Our review notes that the concept of prediabetes is increasingly recognized worldwide, but against a background of non-uniform definition and diagnostic criteria. This results in widely varying burden estimation. Current evidence shows a variety of prediabetes phenotypes. This reflects biological and diagnostic heterogeneity, resulting from the use of different tests (glucose or HbA1C) and thresholds to define prediabetes. The biological and diagnostic variabilities have implications for the characterization of the burden of prediabetes, natural history, prognosis, screening, implementation of lifestyle or drug interventions to mitigate related health risks, and monitoring of the effects of such interventions.
PURPOSE OF REVIEW: Using a global perspective, this review collates evidence on the heterogeneity of prediabetes definitions and diagnostic methods, their clinical and public health implications, and discusses possible options for improvement. RECENT FINDINGS: Our review notes that the concept of prediabetes is increasingly recognized worldwide, but against a background of non-uniform definition and diagnostic criteria. This results in widely varying burden estimation. Current evidence shows a variety of prediabetes phenotypes. This reflects biological and diagnostic heterogeneity, resulting from the use of different tests (glucose or HbA1C) and thresholds to define prediabetes. The biological and diagnostic variabilities have implications for the characterization of the burden of prediabetes, natural history, prognosis, screening, implementation of lifestyle or drug interventions to mitigate related health risks, and monitoring of the effects of such interventions.
Authors: Elizabeth Selvin; Michael W Steffes; Hong Zhu; Kunihiro Matsushita; Lynne Wagenknecht; James Pankow; Josef Coresh; Frederick L Brancati Journal: N Engl J Med Date: 2010-03-04 Impact factor: 91.245
Authors: Nicole Soranzo; Serena Sanna; Eleanor Wheeler; Christian Gieger; Dörte Radke; Josée Dupuis; Nabila Bouatia-Naji; Claudia Langenberg; Inga Prokopenko; Elliot Stolerman; Manjinder S Sandhu; Matthew M Heeney; Joseph M Devaney; Muredach P Reilly; Sally L Ricketts; Alexandre F R Stewart; Benjamin F Voight; Christina Willenborg; Benjamin Wright; David Altshuler; Dan Arking; Beverley Balkau; Daniel Barnes; Eric Boerwinkle; Bernhard Böhm; Amélie Bonnefond; Lori L Bonnycastle; Dorret I Boomsma; Stefan R Bornstein; Yvonne Böttcher; Suzannah Bumpstead; Mary Susan Burnett-Miller; Harry Campbell; Antonio Cao; John Chambers; Robert Clark; Francis S Collins; Josef Coresh; Eco J C de Geus; Mariano Dei; Panos Deloukas; Angela Döring; Josephine M Egan; Roberto Elosua; Luigi Ferrucci; Nita Forouhi; Caroline S Fox; Christopher Franklin; Maria Grazia Franzosi; Sophie Gallina; Anuj Goel; Jürgen Graessler; Harald Grallert; Andreas Greinacher; David Hadley; Alistair Hall; Anders Hamsten; Caroline Hayward; Simon Heath; Christian Herder; Georg Homuth; Jouke-Jan Hottenga; Rachel Hunter-Merrill; Thomas Illig; Anne U Jackson; Antti Jula; Marcus Kleber; Christopher W Knouff; Augustine Kong; Jaspal Kooner; Anna Köttgen; Peter Kovacs; Knut Krohn; Brigitte Kühnel; Johanna Kuusisto; Markku Laakso; Mark Lathrop; Cécile Lecoeur; Man Li; Mingyao Li; Ruth J F Loos; Jian'an Luan; Valeriya Lyssenko; Reedik Mägi; Patrik K E Magnusson; Anders Mälarstig; Massimo Mangino; María Teresa Martínez-Larrad; Winfried März; Wendy L McArdle; Ruth McPherson; Christa Meisinger; Thomas Meitinger; Olle Melander; Karen L Mohlke; Vincent E Mooser; Mario A Morken; Narisu Narisu; David M Nathan; Matthias Nauck; Chris O'Donnell; Konrad Oexle; Nazario Olla; James S Pankow; Felicity Payne; John F Peden; Nancy L Pedersen; Leena Peltonen; Markus Perola; Ozren Polasek; Eleonora Porcu; Daniel J Rader; Wolfgang Rathmann; Samuli Ripatti; Ghislain Rocheleau; Michael Roden; Igor Rudan; Veikko Salomaa; Richa Saxena; David Schlessinger; Heribert Schunkert; Peter Schwarz; Udo Seedorf; Elizabeth Selvin; Manuel Serrano-Ríos; Peter Shrader; Angela Silveira; David Siscovick; Kjioung Song; Timothy D Spector; Kari Stefansson; Valgerdur Steinthorsdottir; David P Strachan; Rona Strawbridge; Michael Stumvoll; Ida Surakka; Amy J Swift; Toshiko Tanaka; Alexander Teumer; Gudmar Thorleifsson; Unnur Thorsteinsdottir; Anke Tönjes; Gianluca Usala; Veronique Vitart; Henry Völzke; Henri Wallaschofski; Dawn M Waterworth; Hugh Watkins; H-Erich Wichmann; Sarah H Wild; Gonneke Willemsen; Gordon H Williams; James F Wilson; Juliane Winkelmann; Alan F Wright; Carina Zabena; Jing Hua Zhao; Stephen E Epstein; Jeanette Erdmann; Hakon H Hakonarson; Sekar Kathiresan; Kay-Tee Khaw; Robert Roberts; Nilesh J Samani; Mark D Fleming; Robert Sladek; Gonçalo Abecasis; Michael Boehnke; Philippe Froguel; Leif Groop; Mark I McCarthy; W H Linda Kao; Jose C Florez; Manuela Uda; Nicholas J Wareham; Inês Barroso; James B Meigs Journal: Diabetes Date: 2010-09-21 Impact factor: 9.461
Authors: Eleanor Wheeler; Aaron Leong; Ching-Ti Liu; Marie-France Hivert; Rona J Strawbridge; Clara Podmore; Man Li; Jie Yao; Xueling Sim; Jaeyoung Hong; Audrey Y Chu; Weihua Zhang; Xu Wang; Peng Chen; Nisa M Maruthur; Bianca C Porneala; Stephen J Sharp; Yucheng Jia; Edmond K Kabagambe; Li-Ching Chang; Wei-Min Chen; Cathy E Elks; Daniel S Evans; Qiao Fan; Franco Giulianini; Min Jin Go; Jouke-Jan Hottenga; Yao Hu; Anne U Jackson; Stavroula Kanoni; Young Jin Kim; Marcus E Kleber; Claes Ladenvall; Cecile Lecoeur; Sing-Hui Lim; Yingchang Lu; Anubha Mahajan; Carola Marzi; Mike A Nalls; Pau Navarro; Ilja M Nolte; Lynda M Rose; Denis V Rybin; Serena Sanna; Yuan Shi; Daniel O Stram; Fumihiko Takeuchi; Shu Pei Tan; Peter J van der Most; Jana V Van Vliet-Ostaptchouk; Andrew Wong; Loic Yengo; Wanting Zhao; Anuj Goel; Maria Teresa Martinez Larrad; Dörte Radke; Perttu Salo; Toshiko Tanaka; Erik P A van Iperen; Goncalo Abecasis; Saima Afaq; Behrooz Z Alizadeh; Alain G Bertoni; Amelie Bonnefond; Yvonne Böttcher; Erwin P Bottinger; Harry Campbell; Olga D Carlson; Chien-Hsiun Chen; Yoon Shin Cho; W Timothy Garvey; Christian Gieger; Mark O Goodarzi; Harald Grallert; Anders Hamsten; Catharina A Hartman; Christian Herder; Chao Agnes Hsiung; Jie Huang; Michiya Igase; Masato Isono; Tomohiro Katsuya; Chiea-Chuen Khor; Wieland Kiess; Katsuhiko Kohara; Peter Kovacs; Juyoung Lee; Wen-Jane Lee; Benjamin Lehne; Huaixing Li; Jianjun Liu; Stephane Lobbens; Jian'an Luan; Valeriya Lyssenko; Thomas Meitinger; Tetsuro Miki; Iva Miljkovic; Sanghoon Moon; Antonella Mulas; Gabriele Müller; Martina Müller-Nurasyid; Ramaiah Nagaraja; Matthias Nauck; James S Pankow; Ozren Polasek; Inga Prokopenko; Paula S Ramos; Laura Rasmussen-Torvik; Wolfgang Rathmann; Stephen S Rich; Neil R Robertson; Michael Roden; Ronan Roussel; Igor Rudan; Robert A Scott; William R Scott; Bengt Sennblad; David S Siscovick; Konstantin Strauch; Liang Sun; Morris Swertz; Salman M Tajuddin; Kent D Taylor; Yik-Ying Teo; Yih Chung Tham; Anke Tönjes; Nicholas J Wareham; Gonneke Willemsen; Tom Wilsgaard; Aroon D Hingorani; Josephine Egan; Luigi Ferrucci; G Kees Hovingh; Antti Jula; Mika Kivimaki; Meena Kumari; Inger Njølstad; Colin N A Palmer; Manuel Serrano Ríos; Michael Stumvoll; Hugh Watkins; Tin Aung; Matthias Blüher; Michael Boehnke; Dorret I Boomsma; Stefan R Bornstein; John C Chambers; Daniel I Chasman; Yii-Der Ida Chen; Yduan-Tsong Chen; Ching-Yu Cheng; Francesco Cucca; Eco J C de Geus; Panos Deloukas; Michele K Evans; Myriam Fornage; Yechiel Friedlander; Philippe Froguel; Leif Groop; Myron D Gross; Tamara B Harris; Caroline Hayward; Chew-Kiat Heng; Erik Ingelsson; Norihiro Kato; Bong-Jo Kim; Woon-Puay Koh; Jaspal S Kooner; Antje Körner; Diana Kuh; Johanna Kuusisto; Markku Laakso; Xu Lin; Yongmei Liu; Ruth J F Loos; Patrik K E Magnusson; Winfried März; Mark I McCarthy; Albertine J Oldehinkel; Ken K Ong; Nancy L Pedersen; Mark A Pereira; Annette Peters; Paul M Ridker; Charumathi Sabanayagam; Michele Sale; Danish Saleheen; Juha Saltevo; Peter Eh Schwarz; Wayne H H Sheu; Harold Snieder; Timothy D Spector; Yasuharu Tabara; Jaakko Tuomilehto; Rob M van Dam; James G Wilson; James F Wilson; Bruce H R Wolffenbuttel; Tien Yin Wong; Jer-Yuarn Wu; Jian-Min Yuan; Alan B Zonderman; Nicole Soranzo; Xiuqing Guo; David J Roberts; Jose C Florez; Robert Sladek; Josée Dupuis; Andrew P Morris; E-Shyong Tai; Elizabeth Selvin; Jerome I Rotter; Claudia Langenberg; Inês Barroso; James B Meigs Journal: PLoS Med Date: 2017-09-12 Impact factor: 11.069