Literature DB >> 3022006

Structure of a human retroviral sequence related to mouse mammary tumor virus.

F E May, B R Westley.   

Abstract

Human sequences that are related to the mouse mammary tumor virus (MuMTV) genome were cloned from breast tumor cell DNA. Of 100 recombinants, only 1 hybridized with two different probes from separate regions of the MuMTV genome (gag-pol and long terminal repeat [LTR]). This sequence, NMWV 4, was shown to have a proviruslike structure. Hybridization to digests of normal and tumor cell DNA indicated that NMWV 4 and a few closely related sequences are endogenous to the human genome. The regions that contain homology to the MuMTV LTR were sequenced. Long repeated sequences with the hallmarks of retroviral LTRs were identified. The NMWV 4 LTR contains transcription initiation and termination signals and is flanked by a polypurine tract (5' LTR) and a primer-binding site (3' LTR). The primer-binding site is complementary to tRNA lysine, the primer used by MuMTV and HTLV-III. The polypurine tract is also similar to those of these two retroviruses.

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Year:  1986        PMID： 3022006      PMCID： PMC288949     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  24 in total

1.  Molecular cloning and long terminal repeat sequences of human endogenous retrovirus genes related to types A and B retrovirus genes.

Authors:  M Ono
Journal:  J Virol       Date:  1986-06       Impact factor: 5.103

2.  A human cell line from a pleural effusion derived from a breast carcinoma.

Authors:  H D Soule; J Vazguez; A Long; S Albert; M Brennan
Journal:  J Natl Cancer Inst       Date:  1973-11       Impact factor: 13.506

3.  DNA sequences bound specifically by glucocorticoid receptor in vitro render a heterologous promoter hormone responsive in vivo.

Authors:  V L Chandler; B A Maler; K R Yamamoto
Journal:  Cell       Date:  1983-06       Impact factor: 41.582

4.  Mouse mammary tumour virus related sequences are present in human DNA.

Authors:  F E May; B R Westley; H Rochefort; E Buetti; H Diggelmann
Journal:  Nucleic Acids Res       Date:  1983-06-25       Impact factor: 16.971

5.  Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome.

Authors:  R Nusse; H E Varmus
Journal:  Cell       Date:  1982-11       Impact factor: 41.582

6.  Characterization of endogenous and exogenous mouse mammary tumor virus proviral DNA with site-specific molecular clones.

Authors:  B Groner; E Buetti; H Diggelmann; N E Hynes
Journal:  J Virol       Date:  1980-12       Impact factor: 5.103

7.  DNA sequencing with chain-terminating inhibitors.

Authors:  F Sanger; S Nicklen; A R Coulson
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

8.  Sequence-specific binding of glucocorticoid receptor to MTV DNA at sites within and upstream of the transcribed region.

Authors:  F Payvar; D DeFranco; G L Firestone; B Edgar; O Wrange; S Okret; J A Gustafsson; K R Yamamoto
Journal:  Cell       Date:  1983-12       Impact factor: 41.582

9.  Human adult T-cell leukemia virus: complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA.

Authors:  M Seiki; S Hattori; Y Hirayama; M Yoshida
Journal:  Proc Natl Acad Sci U S A       Date:  1983-06       Impact factor: 11.205

10.  Tumorigenesis by mouse mammary tumor virus: evidence for a common region for provirus integration in mammary tumors.

Authors:  G Peters; S Brookes; R Smith; C Dickson
Journal:  Cell       Date:  1983-06       Impact factor: 41.582
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  16 in total

1.  Prototypic sequences for human repetitive DNA.

Authors:  J Jurka; J Walichiewicz; A Milosavljevic
Journal:  J Mol Evol       Date:  1992-10       Impact factor: 2.395

2.  Potential retroviral RNAs in Creutzfeldt-Jakob disease.

Authors:  G H Murdoch; T Sklaviadis; E E Manuelidis; L Manuelidis
Journal:  J Virol       Date:  1990-04       Impact factor: 5.103

3.  Human endogenous retroviruslike genome with type C pol sequences and gag sequences related to human T-cell lymphotropic viruses.

Authors:  D L Mager; J D Freeman
Journal:  J Virol       Date:  1987-12       Impact factor: 5.103

4.  Human endogenous retrovirus K10 encodes a functional integrase.

Authors:  Y Kitamura; T Ayukawa; T Ishikawa; T Kanda; K Yoshiike
Journal:  J Virol       Date:  1996-05       Impact factor: 5.103

5.  Identification of a Rev-related protein by analysis of spliced transcripts of the human endogenous retroviruses HTDV/HERV-K.

Authors:  R Löwer; R R Tönjes; C Korbmacher; R Kurth; J Löwer
Journal:  J Virol       Date:  1995-01       Impact factor: 5.103

6.  Identification of three human sequences with viral superantigen-specific primers.

Authors:  S Indraccolo; W H Günzburg; C Leib-Mösch; V Erfle; B Salmons
Journal:  Mamm Genome       Date:  1995-05       Impact factor: 2.957

7.  Identification of a retinoic acid-inducible endogenous retroviral transcript in the human teratocarcinoma-derived cell line PA-1.

Authors:  P Kannan; R Buettner; D R Pratt; M A Tainsky
Journal:  J Virol       Date:  1991-11       Impact factor: 5.103

Review 8.  Evolution and biological significance of human retroelements.

Authors:  C Leib-Mösch; W Seifarth
Journal:  Virus Genes       Date:  1995       Impact factor: 2.332

9.  Characterization of novel reverse transcriptase encoding human endogenous retroviral sequences similar to type A and type B retroviruses: differential transcription in normal human tissues.

Authors:  P Medstrand; J Blomberg
Journal:  J Virol       Date:  1993-11       Impact factor: 5.103

10.  Tissue-specific expression of human provirus ERV3 mRNA in human placenta: two of the three ERV3 mRNAs contain human cellular sequences.

Authors:  N Kato; S Pfeifer-Ohlsson; M Kato; E Larsson; J Rydnert; R Ohlsson; M Cohen
Journal:  J Virol       Date:  1987-07       Impact factor: 5.103
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