Paik Seong Lim1,2,3, Yu-Kang Chang4, Tsai-Kun Wu5. 1. Division of Renal Medicine, Tungs' Taichung Metroharbour Hospital, Taichung, Taiwanjamespslim@gmail.com. 2. Department of Nursing and Rehabilitation, Jenteh Junior College of Medicine, Nursing and Management, Miaoli, Taiwanjamespslim@gmail.com. 3. Department of Internal Medicine, Taipei Medical University, Taipei, Taiwanjamespslim@gmail.com. 4. Division of Epidemiology and Biostatistics, Department of Medical Research, Tungs' Taichung Metroharbour Hospital, Taichung, Taiwan. 5. Division of Renal Medicine, Tungs' Taichung Metroharbour Hospital, Taichung, Taiwan.
Abstract
BACKGROUND: In hemodialysis (HD) patients, impaired gut barrier and alteration in microbiota in the gut is thought to increase the risk of bacterial translocation and chronic inflammation. Lipopolysaccharide-binding protein (LBP) is an acute-phase reactant that mediates immune responses triggered by microbial products. Our aim is to investigate the relationship between circulating levels of LBP, and various metabolic and inflammatory markers in HD patients. Besides, we also aim to determine its relationship among -patients with different body mass index. PATIENTS AND METHODS: A total of 123 HD patients were stratified into three -tertiles, according to serum LBP level. The LBP and inflammatory markers were determined using immunoassay methods. A bioimpedance spectroscopy device was used for body composition measurement. RESULTS: The serum levels of the two proinflammatory markers, high-sensitivity C-reactive protein (hsCRP) and interleukin (IL)-6, were significantly higher in patients in the upper tertile when compared with the rest of the tertiles. In HD patients, a significant positive correlation was found between serum LBP levels and CRP, IL-6, soluble CD14 (sCD14), and fasting blood glucose levels. Patients with metabolic syndrome and pre-existing cardiovascular disease had higher LBP levels than those without metabolic syndrome. Besides, obese patients were also associated with higher serum LBP levels. Multivariate regression analyses showed that IL-6 level was the strongest correlate of LBP level, followed by hsCRP level and sCD14. CONCLUSIONS: Our study suggested that elevated plasma LBP was associated with metabolic syndrome and obesity. In addition, increased LBP level was correlated positively to markers of inflammation, and sCD14 levels.
BACKGROUND: In hemodialysis (HD) patients, impaired gut barrier and alteration in microbiota in the gut is thought to increase the risk of bacterial translocation and chronic inflammation. Lipopolysaccharide-binding protein (LBP) is an acute-phase reactant that mediates immune responses triggered by microbial products. Our aim is to investigate the relationship between circulating levels of LBP, and various metabolic and inflammatory markers in HDpatients. Besides, we also aim to determine its relationship among -patients with different body mass index. PATIENTS AND METHODS: A total of 123 HDpatients were stratified into three -tertiles, according to serum LBP level. The LBP and inflammatory markers were determined using immunoassay methods. A bioimpedance spectroscopy device was used for body composition measurement. RESULTS: The serum levels of the two proinflammatory markers, high-sensitivity C-reactive protein (hsCRP) and interleukin (IL)-6, were significantly higher in patients in the upper tertile when compared with the rest of the tertiles. In HDpatients, a significant positive correlation was found between serum LBP levels and CRP, IL-6, soluble CD14 (sCD14), and fasting blood glucose levels. Patients with metabolic syndrome and pre-existing cardiovascular disease had higher LBP levels than those without metabolic syndrome. Besides, obesepatients were also associated with higher serum LBP levels. Multivariate regression analyses showed that IL-6 level was the strongest correlate of LBP level, followed by hsCRP level and sCD14. CONCLUSIONS: Our study suggested that elevated plasma LBP was associated with metabolic syndrome and obesity. In addition, increased LBP level was correlated positively to markers of inflammation, and sCD14 levels.
Authors: Nicholas G Lamson; Katherine C Fein; John P Gleeson; Alexandra N Newby; Sijie Xian; Kyle Cochran; Namit Chaudhary; Jilian R Melamed; Rebecca L Ball; Kanika Suri; Vishal Ahuja; Anna Zhang; Adrian Berger; Dmytro Kolodieznyi; Brigitte F Schmidt; Gloria L Silva; Kathryn A Whitehead Journal: Proc Natl Acad Sci U S A Date: 2022-08-09 Impact factor: 12.779
Authors: Abigail J S Armstrong; Kevin Quinn; Jennifer Fouquier; Sam X Li; Jennifer M Schneider; Nichole M Nusbacher; Katrina A Doenges; Suzanne Fiorillo; Tyson J Marden; Janine Higgins; Nichole Reisdorph; Thomas B Campbell; Brent E Palmer; Catherine A Lozupone Journal: mSystems Date: 2021-05-18 Impact factor: 6.496