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Literature DB >> 3021572

Evidence for evolutionary duplication of genes in the dopa decarboxylase region of Drosophila.

Abstract

The region surrounding the dopa decarboxylase gene (Ddc) of Drosophila contains a cluster of genes, many of which appear to be functionally related by virtue of their effects on cuticle development and/or catecholamine metabolism. In this report we describe evidence that the Ddc gene and the closely linked alpha-methyldopa hypersensitive (amd) gene share extensive sequence homology and are the products of a gene duplication event. The two genes are transcribed convergently and are separated by 2.4 kb. A gene located between Ddc and amd expresses a 2.0-kb mRNA and appears to partially overlap the Ddc gene. The organization of these transcripts implies a complex series of events giving rise to the present pattern. The patterns of expression of these genes do not support a model of coordinate regulation, but are more consistent with a pattern of duplication and divergence to various related metabolic subspecialties. These data provide the first evidence for structural relationships among genes in the 37C cluster.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 1986 PMID： 3021572 PMCID： PMC1202951

Source DB: PubMed Journal: Genetics ISSN： 0016-6731 Impact factor: 4.562

19 in total

1. The chymotryptic phosphopyridoxyl peptide of DOPA decarboxylase from pig kidney.

Authors: F Bossa; F Martini; D Barra; C B Voltattorni; A Minelli; C Turano
Journal: Biochem Biophys Res Commun Date: 1977-09-09 Impact factor: 3.575

2. The ovalbumin gene region: common features in the organisation of three genes expressed in chicken oviduct under hormonal control.

Authors: A Royal; A Garapin; B Cami; F Perrin; J L Mandel; M LeMeur; F Brégégègre; F Gannon; J P LePennec; P Chambon; P Kourilsky
Journal: Nature Date: 1979-05-10 Impact factor: 49.962

3. Origins of metabolic diversity: substitution of homologous sequences into genes for enzymes with different catalytic activities.

Authors: W K Yeh; L N Ornston
Journal: Proc Natl Acad Sci U S A Date: 1980-09 Impact factor: 11.205

Review 4. The molecular genetics of human hemoglobins.

Authors: T Maniatis; E F Fritsch; J Lauer; R M Lawn
Journal: Annu Rev Genet Date: 1980 Impact factor: 16.830

5. Why genes in pieces?

Authors: W Gilbert
Journal: Nature Date: 1978-02-09 Impact factor: 49.962

6. The structure and evolution of the human beta-globin gene family.

Authors: A Efstratiadis; J W Posakony; T Maniatis; R M Lawn; C O'Connell; R A Spritz; J K DeRiel; B G Forget; S M Weissman; J L Slightom; A E Blechl; O Smithies; F E Baralle; C C Shoulders; N J Proudfoot
Journal: Cell Date: 1980-10 Impact factor: 41.582

7. The selection for mutants in Drosophila melanogaster hypersensitive to alpha-methyl dopa, a dopa decarboxylase inhibitor.

Authors: J C Sparrow; T R Wright
Journal: Mol Gen Genet Date: 1974-05-21

8. The evolution of genes: the chicken preproinsulin gene.

Authors: F Perler; A Efstratiadis; P Lomedico; W Gilbert; R Kolodner; J Dodgson
Journal: Cell Date: 1980-06 Impact factor: 41.582

9. Isolation and characterization of the dopa decarboxylase gene of Drosophila melanogaster.

Authors: J Hirsh; N Davidson
Journal: Mol Cell Biol Date: 1981-06 Impact factor: 4.272

10. The genetics of dopa decarboxylase in Drosophila melanogaster. IV. The genetics and cytology of the 37B10-37D1 region.

Authors: T R Wright; W Beermann; J L Marsh; C P Bishop; R Steward; B C Black; A D Tomsett; E Y Wright
Journal: Chromosoma Date: 1981 Impact factor: 4.316

11 in total

1. Different mRNAs code for dopa decarboxylase in tissues of neuronal and nonneuronal origin.

Authors: M Krieger; F Coge; F Gros; J Thibault
Journal: Proc Natl Acad Sci U S A Date: 1991-03-15 Impact factor: 11.205

2. Evolutionary changes in the expression pattern of a developmentally essential gene in three Drosophila species.

Authors: D Wang; J L Marsh; F J Ayala
Journal: Proc Natl Acad Sci U S A Date: 1996-07-09 Impact factor: 11.205

3. Molecular localization, developmental expression and nucleotide sequence of the alpha-methyldopa hypersensitive gene of Drosophila.

Authors: J L Marsh; M P Erfle; C A Leeds
Journal: Genetics Date: 1986-10 Impact factor: 4.562

4. The alpha methyl dopa hypersensitive gene, 1(2)amd, and two adjacent genes in Drosophila melanogaster: physical location and direct effects of amd on catecholamine metabolism.

Authors: B C Black; E S Pentz; T R Wright
Journal: Mol Gen Genet Date: 1987-09

5. Prokaryotic and eukaryotic pyridoxal-dependent decarboxylases are homologous.

Authors: F R Jackson
Journal: J Mol Evol Date: 1990-10 Impact factor: 2.395

6. Molecular cloning and analysis of cDNA encoding a plant tryptophan decarboxylase: comparison with animal dopa decarboxylases.

Authors: V De Luca; C Marineau; N Brisson
Journal: Proc Natl Acad Sci U S A Date: 1989-04 Impact factor: 11.205

7. Duplication of the structural gene for glucosephosphate isomerase and phosphogluconate dehydrogenase in Scabiosa columbaria and their phylogenetic implications in the dipsacaceae.

Authors: R Van Treuren; R Bijlsma
Journal: Biochem Genet Date: 1992-02 Impact factor: 1.890

8. Overlapping transcription units in Drosophila: sequence and structure of the Cs gene.

Authors: D D Eveleth; J L Marsh
Journal: Mol Gen Genet Date: 1987-09

9. Ultrastructural analysis of polytene chromatin of Drosophila melanogaster reveals clusters of tightly linked co-expressed genes.

Authors: E J Hager; O L Miller
Journal: Chromosoma Date: 1991-03 Impact factor: 4.316

10. Molecular characterization of neurally expressing genes in the para sodium channel gene cluster of drosophila.

Authors: C S Hong; B Ganetzky
Journal: Genetics Date: 1996-03 Impact factor: 4.562