Literature DB >> 30209717

A Transgenic MMTV-Flippase Mouse Line for Molecular Engineering in Mammary Gland and Breast Cancer Mouse Models.

Fabiana Lüönd1, Ruben Bill1, Andrea Vettiger1,2, Heide Oller3, Pawel Pelczar3, Gerhard Christofori4.   

Abstract

Genetically engineered mouse models have become an indispensable tool for breast cancer research. Combination of multiple site-specific recombination systems such as Cre/loxP and Flippase (Flp)/Frt allows for engineering of sophisticated, multi-layered conditional mouse models. Here, we report the generation and characterization of a novel transgenic mouse line expressing a mouse codon-optimized Flp under the control of the mouse mammary tumor virus (MMTV) promoter. These mice show robust Flp-mediated recombination in luminal mammary gland and breast cancer cells but no Flp activity in non-mammary tissues, with the exception of limited activity in salivary glands. These mice provide a unique tool for studying mammary gland biology and carcinogenesis in mice.

Entities:  

Keywords:  Breast cancer; Flippase; Lineage tracing; MMTV promoter; Mammary gland; Transgenic mice

Year:  2018        PMID： 30209717     DOI： 10.1007/s10911-018-9412-4

Source DB:  PubMed          Journal:  J Mammary Gland Biol Neoplasia        ISSN： 1083-3021            Impact factor:   2.673


  20 in total

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Review 5.  Choosing a mouse model: experimental biology in context--the utility and limitations of mouse models of breast cancer.

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9.  Uncoupling cancer mutations reveals critical timing of p53 loss in sarcomagenesis.

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  4 in total

1.  Tracking and characterization of partial and full epithelial-mesenchymal transition cells in a mouse model of metastatic breast cancer.

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3.  Dual recombinase action in the normal and neoplastic mammary gland epithelium.

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Review 4.  How Lineage Tracing Studies Can Unveil Tumor Heterogeneity in Breast Cancer.

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  4 in total

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