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Literature DB >> 14723844

Talking about a revolution: The impact of site-specific recombinases on genetic analyses in mice.

Abstract

Site-specific recombinase systems (Cre-loxP, Flp-FRT, and phi C31-att) are transforming both forward and reverse genetics in mice. By enabling high-fidelity DNA modifications to be induced in vitro or in vivo, these systems have incited a wave of new biology, advancing our understanding of gene function, genetic relationships, development, and disease.

Entities: Gene Species

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Year: 2004 PMID： 14723844 DOI： 10.1016/s1534-5807(03)00399-x

Source DB: PubMed Journal: Dev Cell ISSN： 1534-5807 Impact factor: 12.270

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Cited

323 in total

1. High efficiency of a sequential recombinase-mediated cassette exchange reaction in Escherichia coli.

Authors: Natalia Malchin; Tatiana Molotsky; Ilya Borovok; Yuri Voziyanov; Alexander B Kotlyar; Ezra Yagil; Mikhail Kolot
Journal: J Mol Microbiol Biotechnol Date: 2010-10-06

2. Defining POMC neurons using transgenic reagents: impact of transient Pomc expression in diverse immature neuronal populations.

Authors: Stephanie L Padilla; Daniel Reef; Lori M Zeltser
Journal: Endocrinology Date: 2011-12-13 Impact factor: 4.736

3. Elimination of background recombination: somatic induction of Cre by combined transcriptional regulation and hormone binding affinity.

Authors: Richard Kemp; Heather Ireland; Elizabeth Clayton; Carol Houghton; Louise Howard; Douglas J Winton
Journal: Nucleic Acids Res Date: 2004-07-01 Impact factor: 16.971

Talking about a revolution: The impact of site-specific recombinases on genetic analyses in mice.

1. High efficiency of a sequential recombinase-mediated cassette exchange reaction in Escherichia coli.

2. Defining POMC neurons using transgenic reagents: impact of transient Pomc expression in diverse immature neuronal populations.

3. Elimination of background recombination: somatic induction of Cre by combined transcriptional regulation and hormone binding affinity.

4. A homozygous mutant embryonic stem cell bank applicable for phenotype-driven genetic screening.

5. Mouse models of human bladder cancer as a tool for drug discovery.

6. Transcription factor Olig2 defines subpopulations of retinal progenitor cells biased toward specific cell fates.

7. Identification of a retina-specific Otx2 enhancer element active in immature developing photoreceptors.

Review 8. Cardiac-specific inducible and conditional gene targeting in mice.

9. GABAergic interneuron lineages selectively sort into specific cortical layers during early postnatal development.

10. Structure-function Studies in Mouse Embryonic Stem Cells Using Recombinase-mediated Cassette Exchange.